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Gene Review:

SOX17 - SRY (sex determining region Y)-box 17

Homo sapiens

Synonyms: Transcription factor SOX-17

Katoh, M., Xu, X. et al., Poulain, M. et al., Suraweera, N. et al.

Katoh,

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High impact information on SOX17

We found that FGF/ERK signalling causes phosphorylation of Casanova/Sox32, an important regulator of endoderm determination, and provide evidence that this phosphorylation attenuates its ability to induce sox17 [1].
A heterozygous SOX17 mutation (L194P) was also found in a cell line [2].
SOX17 gene, consisting of 2 exons, was located in human chromosome 8q12-q13 region [3].
In normal gastrointestinal tract, SOX17 mRNA was preferentially expressed in esophagus, stomach and small intestine than in colon and rectum [3].
SOX17 mRNAs of 2.5- and 2.2-kb in size were detected in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney [3].

Biological context of SOX17

Here, human SOX17 gene fragments were identified in human genome draft sequences by using bioinformatics, and SOX17 cDNAs were isolated by using cDNA-PCR [3].

Anatomical context of SOX17

HESCs are capable of spontaneous differentiation to cells expressing the definitive endoderm and pancreatic progenitor markers Foxa2, Sox17, and Pdx1, and ultimately, some cells express islet endocrine hormones [4].

Analytical, diagnostic and therapeutic context of SOX17

Molecular cloning and characterization of human SOX17 [3].

References

Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling. Poulain, M., Fürthauer, M., Thisse, B., Thisse, C., Lepage, T. Development (2006) [Pubmed]
Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines. Suraweera, N., Robinson, J., Volikos, E., Guenther, T., Talbot, I., Tomlinson, I., Silver, A. Int. J. Cancer (2006) [Pubmed]
Molecular cloning and characterization of human SOX17. Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
Endoderm and pancreatic islet lineage differentiation from human embryonic stem cells. Xu, X., Kahan, B., Forgianni, A., Jing, P., Jacobson, L., Browning, V., Treff, N., Odorico, J. Cloning Stem Cells (2006) [Pubmed]

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SOX17	Bos taurus
SOX17	Canis lupus familiaris
SOX17	Gallus gallus
SOX17	Macaca mulatta
Sox17	Mus musculus
SOX17	Pan troglodytes
Sox17	Rattus norvegicus
sox17a	Xenopus (Silurana) tropicalis

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