Disease relevance of Snrpg

• We studied the toxicity of SMG on mouse embryos explanted on day 8 of gestation and cultured in rat serum for 42 hr [1].

High impact information on Snrpg

• Thus, CD3+ T cells were isolated from salivary gland-associated tissues (SGAT) which consist of the submandibular gland (SMG: approximately 46%), the periglandular lymph node (PGLN: approximately 72%), and the cervical lymph node (CLN: approximately 90%) [2].
• In addition, the 6-OHDA treatment greatly reduced the wet weight and total protein content of the sympathetic superior cervical ganglia which innervate SMG tissue [3].
• The glandular norepinephrine contents were greatly reduced indicating that the dose and duration of 6-OHDA treatment were sufficient to cause a total sympathectomy in SMG tissue [3].
• Thyroxine (T4) administration in mice during the 2nd wk of postnatal life elicits a precocious increase in submandibular gland-nerve growth factor (SMG-NGF) and epidermal growth factor (SMG-EGF) levels, but the mechanism(s) of T4 action has not been studied [3].
• Thus EGF found in the mouse thyroid gland does not appear to arise from the SMG, and the thyroid appears to be an independent source of EGF synthesis [4].

Chemical compound and disease context of Snrpg

• It is concluded that SMG exerts embryotoxic and dysmorphogenic effects and may contribute to systemic toxicity of methyl isocyanate [1].

Biological context of Snrpg

• At a concentration of 2 mM, SMG completely arrested embryo development, but heartbeat was absent in only one of nine embryos at 42 hr [1].
• SMG caused concentration-dependent decreases in growth and development over the range 0.1-2 mM, without causing significant mortality [1].

Anatomical context of Snrpg

• DNA content of and thymidine incorporation by embryos and yolk sacs was reduced by SMG, although this was more pronounced in the yolk sac than in embryos [1].
• Several important and unique features of T cells in SMG were demonstrated by this study [5].

Associations of Snrpg with chemical compounds

• Methyl isocyanate, the chemical involved in the 1984 accident at Bhopal, India, forms a labile conjugate, S-(N-methylcarbamoyl)GSH (SMG), by way of a reversible reaction with GSH [1].
• At subtoxic concentrations, the L-cysteine precursor (-)-2-oxo-4-thiazolidine-carboxylic acid did not, but GSH did, inhibit embryotoxicity of SMG [1].

Analytical, diagnostic and therapeutic context of Snrpg

• We examined the kallikrein isozyme pattern in SMG of two strains using isoelectric focusing [6].

References