High impact information on Hrnr

• Hornerin, a novel profilaggrin-like protein and differentiation-specific marker isolated from mouse skin [1].
• Hornerin was expressed in the tongue, esophagus, forestomach, and skin among the adult mouse tissues examined, all of them cornifying stratified epithelium [1].
• Differentiation of primary mouse epidermal keratinocytes with 0.12 mm Ca(2+) resulted in the induction of hornerin [1].
• The repetitive domain of hornerin was found to be rich in glycine, serine, and glutamine [1].
• Hornerin, which has 2,496 amino acids, comprises EF-hand domains at the N terminus followed by a spacer sequence and a large repetitive domain, indicating that hornerin is a novel member of the "fused gene"-type cornified envelope precursor protein family [1].

Anatomical context of Hrnr

• Expression of hornerin in stratified squamous epithelium in the mouse: a comparative analysis with profilaggrin [2].
• In addition, both hornerin and profilaggrin were expressed in the tongue, esophagus, and forestomach [2].

Other interactions of Hrnr

• In this study we examined the expression of hornerin compared with that of profilaggrin in various mouse tissues [2].

Analytical, diagnostic and therapeutic context of Hrnr

• Furthermore, Western blot analysis of the mouse skin showed that the hornerin protein was cleaved during the process of epidermal differentiation, indicating possible posttranslational proteolytic processing as is observed in profilaggrin [1].

References