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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Wrb  -  tryptophan rich basic protein

Mus musculus

Synonyms: 5530402J05Rik, C030018G21Rik, Chd5, Tail-anchored protein insertion receptor WRB, Tryptophan-rich basic protein, ...
 
 
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Disease relevance of Wrb

 

High impact information on Wrb

  • SmIrV1 can be divided into three regions: a neutral N-terminal region with a putative signal sequence, followed by a proline- and tryptophan-rich P region in which two sets of sequences are repeated four times and a C-terminal region which is highly acidic with an isoelectric point of 4 [2].
  • Four mouse cryptdins, two neutrophil defensins (HNP-1 [human] and NP-2 [rabbit]), and the unique tryptophan-rich bovine neutrophil polypeptide indolicidin each had some antigiardial activity against trophozoites in vitro [3].
  • Another new monoclonal antibody, MoAb36, detected the Wrb antigen, located on the non-glycosylated segment of glycophorin A near its insertion into the lipid bilayer [4].

References

  1. The carboxyl segment of the mumps virus V protein associates with Stat proteins in vitro via a tryptophan-rich motif. Nishio, M., Garcin, D., Simonet, V., Kolakofsky, D. Virology (2002) [Pubmed]
  2. Molecular cloning and expression of SmIrV1, a Schistosoma mansoni antigen with similarity to calnexin, calreticulin, and OvRal1. Hawn, T.R., Tom, T.D., Strand, M. J. Biol. Chem. (1993) [Pubmed]
  3. Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides. Aley, S.B., Zimmerman, M., Hetsko, M., Selsted, M.E., Gillin, F.D. Infect. Immun. (1994) [Pubmed]
  4. Glycophorin A on normal and leukemia cells detected by monoclonal antibodies, including a new monoclonal antibody reactive with glycophorins A and B. Rearden, A., Taetle, R., Elmajian, D.A., Majda, J.A., Baird, S.M. Mol. Immunol. (1985) [Pubmed]
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