The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ZNHIT2  -  zinc finger, HIT-type containing 2

Homo sapiens

Synonyms: C11orf5, FON, Protein FON, Zinc finger HIT domain-containing protein 2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ZNHIT2


High impact information on ZNHIT2

  • In this report, we performed a study using this approach and isolated five novel human genes, C11orf1-C11orf5, in the 11q13-q22 region [3].
  • Another two pools of larvae were exposed to FON for a 2 hour period at early gastrula (Group II) or neurula (Group III) stages to verify which period of development is the most sensitive to FON [4].
  • The aim of the present work is to evaluate the embryo-lethal and teratogenic potentials of Triadimefon (FON), a triazole-derivative widely used as an antimycotic in agriculture, by the test FETAX (Frog Embryos Teratogenic Assay, Xenopus) with particular attention being paid to the analysis of branchial arch malformations [4].
  • Our results support the hypothesis that FON can interfere with Neural Crest Cell (NCC) migration, since craniofacial components and melanophores are derived from neural crest material [4].

Anatomical context of ZNHIT2

  • Neurulation was more sensitive to FON exposure than gastrulation, since the TC50 estimated values for group III (neurula exposed) specimens was 7.6 times lower than those of group II (gastrula exposed) [4].


  1. HLA-G gene activation in tumor cells involves cis-acting epigenetic changes. Mouillot, G., Marcou, C., Rousseau, P., Rouas-Freiss, N., Carosella, E.D., Moreau, P. Int. J. Cancer (2005) [Pubmed]
  2. Serial changes in serum vitamin K1, triglyceride, cholesterol, osteocalcin and 25-hydroxyvitamin D3 in patients after hip replacement for fractured neck of femur or osteoarthritis. Roberts, N.B., Holding, J.D., Walsh, H.P., Klenerman, L., Helliwell, T., King, D., Shearer, M. Eur. J. Clin. Invest. (1996) [Pubmed]
  3. Characterization of five novel human genes in the 11q13-q22 region. O'Brien, K.P., Tapia-Páez, I., Ståhle-Bäckdahl, M., Kedra, D., Dumanski, J.P. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  4. Triadimefon causes branchial arch malformations in Xenopus laevis embryos. Papis, E., Bernardini, G., Gornati, R., Prati, M. Environmental science and pollution research international. (2006) [Pubmed]
WikiGenes - Universities