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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Spp2  -  secreted phosphoprotein 2

Mus musculus

Synonyms: 0610038O04Rik, Secreted phosphoprotein 2, Secreted phosphoprotein 24, Spp-24, Spp24, ...
 
 
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Disease relevance of Spp2

  • Marek's disease virus (MDV) gene clones, RA2 and GA8, constructed in E. coli bacteriophage lambda-gt11 (gt11) were identified by a monoclonal antibody (MAb), H19.47, against a putative transformation-related viral antigen consisting of a complex of three phosphorylated polypeptides, pp41, pp38, and pp24 [1].
 

High impact information on Spp2

  • However, the insulin-stimulated, serine-specific phosphorylation of two endogenous phosphoproteins (pp24 and pp240) in the intact cell was blocked by 25 microM PAO [2].
  • We have localized the human SPP2 gene, which encodes spp24 to chromosome 2q37.1, determined its structure and mapped the start of transcription in liver [3].
  • The gene comprises eight exons spread over a region of approximately 27 kb with the cystatin-like region of spp24 encoded by four exons, rather than the three-exon structure typical of the genes encoding the archetypal cystatins [3].

References

  1. Marek's disease virus gene clones encoding virus-specific phosphorylated polypeptides and serological characterization of fusion proteins. Cui, Z.Z., Yan, D., Lee, L.F. Virus Genes (1990) [Pubmed]
  2. Effect of phenylarsine oxide on insulin-dependent protein phosphorylation and glucose transport in 3T3-L1 adipocytes. Frost, S.C., Kohanski, R.A., Lane, M.D. J. Biol. Chem. (1987) [Pubmed]
  3. Characterization of the human secreted phosphoprotein 24 gene (SPP2) and comparison of the protein sequence in nine species. Bennett, C.S., Khorram Khorshid, H.R., Kitchen, J.A., Arteta, D., Dalgleish, R. Matrix Biol. (2004) [Pubmed]
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