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Gene Review

ZNF33A  -  zinc finger protein 33A

Homo sapiens

Synonyms: FLJ23404, KIAA0065, KOX2, KOX31, KOX5, ...
 
 
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High impact information on ZNF33A

  • This distal region also contains seven out of the eight intrachromosomal duplications within the sequence, including the p arm copy of the approximately 250-kb duplication which gave rise to ZNF33A and ZNF33B [1].
  • The model proposed here is that ZAK might play a role as an upstream signal to suppress the ZZaPK function and decrease E2F expression [2].
  • Gene analysis indicated that they consisted of both polymorphic (PSMC4, F3, LOC284058, PLUNC, ZNF33A) and non-polymorphic (XP_931864) antigens [3].
 

Biological context of ZNF33A

  • This cloned cDNA encodes a novel protein with Krüppel-type zinc fingers designed as ZZaPK (zinc finger and ZAK associated protein with KRAB domain) and is widely expressed [2].
 

Other interactions of ZNF33A

  • 2. Sequences hybridizing to the KOX2 probe are found at two loci, ZNF11A and ZNF11B, that map proximal and distal to the 10q11.2 breakpoint, respectively [4].

References

  1. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. Guy, J., Hearn, T., Crosier, M., Mudge, J., Viggiano, L., Koczan, D., Thiesen, H.J., Bailey, J.A., Horvath, J.E., Eichler, E.E., Earthrowl, M.E., Deloukas, P., French, L., Rogers, J., Bentley, D., Jackson, M.S. Genome Res. (2003) [Pubmed]
  2. A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle. Yang, J.J. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  3. Identification of non-HLA target antigens recognized after lung transplantation. Otten, H.G., van den Bosch, J.M., van Ginkel, W.G., van Loon, M., van de Graaf, E.A. J. Heart Lung Transplant. (2006) [Pubmed]
  4. A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10. Rousseau-Merck, M.F., Tunnacliffe, A., Berger, R., Ponder, B.A., Thiesen, H.J. Genomics (1992) [Pubmed]
 
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