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Gene Review: 

Ppp1r14c  -  protein phosphatase 1, regulatory...

Mus musculus

Synonyms: 6330514J04Rik, KEPI, Kepi, Kinase-enhanced PP1 inhibitor, PKC-potentiated PP1 inhibitory protein, ...
 
 

  

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High impact information on Ppp1r14c

  • We identified the protein kinase C-enhanced protein phosphatase 1 (PP1) inhibitor KEPI based on its morphine-induced upregulation in striatum [1].
  • Kepi family members include Ppp1r14a (CPI-17), Ppp1r14b (PHI), ppp1r14c (KEPI), Ppp1r14d (GBPI) and AK016819 (testis enriched transcript)  [2]
  • Dense KEPI immunoreactivity in nucleus accumbens perikarya, combined with evidence for its regulation by opiates, supports possible roles for KEPI in molecular signal transduction pathways important for drug reward and addiction [3].
  • KEPI knockout mice show phenotype of attenuated morphine reward as assessed by conditioned place preference  [4]

References

  1. KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. Liu, Q.R., Zhang, P.W., Zhen, Q., Walther, D., Wang, X.B., Uhl, G.R. J. Biol. Chem. (2002) [Pubmed]
  2. Families of protein phosphatase 1 modulators activated by protein kinases a and C: focus on brain. Liu, Q.R., Gong, J.P., Uhl, G.R. Prog. Nucleic. Acid. Res. Mol. Biol. (2005) [Pubmed]
  3. Mouse brain localization of the protein kinase C-enhanced phosphatase 1 inhibitor KEPI (kinase C-enhanced PP1 inhibitor). Gong, J.P., Liu, Q.R., Zhang, P.W., Wang, Y., Uhl, G.R. Neuroscience (2005) [Pubmed]
  4. Effect of KEPI (Ppp1r14c) deletion on morphine analgesia and tolerance in mice of different genetic backgrounds: when a knockout is near a relevant quantitative trait locus. Drgonova, J., Zimonjic, D.B., Hall, F.S., Uhl, G.R. Neuroscience. (2010) [Pubmed]
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