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PPP1R14C  -  protein phosphatase 1, regulatory...

Homo sapiens

Synonyms: CPI17-like, KEPI, Kinase-enhanced PP1 inhibitor, NY-BR-81, PKC-potentiated PP1 inhibitory protein, ...
 
 

       

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High impact information on PPP1R14C

  • The human KEPI gene contains four exons extending over more than 100 kb of genomic sequence on 6q24-q25, near the mu opiate receptor gene [1].
  • 2.6-kb KEPI mRNAs were detected in brain, especially in the cerebral cortex and hippocampus, and in heart and skeletal muscle [1].
  • KEPI (165 AA polypeptide) is protein kinase C (PKC)-potentiated inhibitory protein (IC50 of 2.7 ± 0.7 nM) for type 1 Ser/Thr protein phosphatase (PP1)  [1]
  • These results suggest that the regulatory phosphorylation of CPI-17 and KEPI may involve distinct kinases and signalingpathways [2].
  • KEPI is identified as a breast cancer antigen by immunoscreening tumor derived cDNA library of breast cancercells [3] and involved in the regulation of the tumor suppressor EGR1 via the MEK-ERK pathway [4]
  • KEPI might be involved in controlling the phosphorylation state of key proteins and regulating drug sensitivity and apoptosis in leukemic cells  [5]
  • Deletion of KEPI gene in a 2.6 Mb of 6q24q-25 is associated with a patient with growth failure, cardiac septal defect, thinupperlip and asymmetric dysmorphic ears [6]

References

  1. KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. Liu, Q.R., Zhang, P.W., Zhen, Q., Walther, D., Wang, X.B., Uhl, G.R. J. Biol. Chem. (2002) [Pubmed]
  2. Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases. Erdodi, F., Kiss, E., Walsh, M.P., Stefansson, B., Deng, J.T., Eto, M., Brautigan, D.L., Hartshorne, D.J. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  3. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. Scanlan, M.J., Gout, I., Gordon, C.M., Williamson, B., Stockert, E., Gure, A.O., Jäger, D., Chen, Y.T., Mackay, A., O'Hare, M.J., Old, L.J. Cancer. Immun. (2001) [Pubmed]
  4. Expression of the protein phosphatase 1 inhibitor KEPI is downregulated in breast cancer cell lines and tissues and involved in the regulation of the tumor suppressor EGR1 via the MEK-ERK pathway. Wenzel, K., Daskalow, K., Herse, F., Seitz, S., Zacharias, U., Schenk, J.A., Schulz, H., Hubner, N., Micheel, B., Schlag, P.M., Osterziel, K.J., Ozcelik, C., Scherneck, S., Jandrig, B. Biol. Chem. (2007) [Pubmed]
  5. Inhibition of protein phosphatase-1 and -2A decreases the chemosensitivity of leukemic cells to chemotherapeutic drugs. Dedinszki, D., Kiss, A., Márkász, L., Márton, A., Tóth, E., Székely, L., Erdődi, F. Cell. Signal. (2015) [Pubmed]
  6. A 2.6 Mb deletion of 6q24.3-25.1 in a patient with growth failure, cardiac septal defect, thin upperlip and asymmetric dysmorphic ears. Caselli, R., Mencarelli, M.A., Papa, F.T., Uliana, V., Schiavone, S., Strambi, M., Pescucci, C., Ariani, F., Rossi, V., Longo, I., Meloni, I., Renieri, A., Mari, F. Eur. J. Med. Genet. (2007) [Pubmed]
 
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