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SGPP1  -  sphingosine-1-phosphate phosphatase 1

Homo sapiens

Synonyms: SPPase1, Sphingosine-1-phosphatase 1, Sphingosine-1-phosphate phosphatase 1, Spp1, hSPP1, ...
 
 
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High impact information on SGPP1

 

Biological context of SGPP1

 

Anatomical context of SGPP1

  • Confocal microscopy revealed green fluorescent protein-tagged hSPPase1, expressed in either MCF7 or HEK293 cells, co-localized to endoplasmic reticulum with calreticulin [3].
  • While the SGPP-1 and SGPP-3 transcripts were most abundant in fat body from crowd-reared males, corresponding to significantly higher levels than in isolated-reared males, the SGPP-2 transcript was detected most abundantly in brain from crowd-reared male locusts [4].
 

Associations of SGPP1 with chemical compounds

  • In addition, siRNA-induced knockdown of hSPPase1 endowed resistance to tumor necrosis factor-alpha and the chemotherapeutic agent daunorubicin [3].
  • For example, the binding rate coefficient, k, exhibits a 4.60 order of dependence on the fractal dimension, D(f), for the binding of unliganded and liganded VDR mixed with GST-RXR in solution to Spp-1 VDRE (1,25-dihydroxyvitamin D(3) receptor element) DNA immobilized on a sensor chip surface (Cheskis and Freedman, Biochemistry 35 (1996) 3300-3318) [5].
  • For example, a >50-fold increase in osteopontin (Spp1) and inositol 1-4-5 phosphate 3 kinase B (Itpkb) levels in acute plaques contrasted with the 5-fold or less increase in chronic active plaques (P < 0.05, unpaired t test) [6].
  • Thus, loss of SPPase in yeast results in high sphingosine-1-phosphate levels and cells are more resistant to stress, and in mammalian cells, overexpression of SPPase elevates ceramide levels and provokes apoptosis [7].
 

Other interactions of SGPP1

 

Analytical, diagnostic and therapeutic context of SGPP1

  • According to Northern blot analysis, hSPPase1 is expressed in most tissues, with the strongest levels found in the highly vascular tissues of placenta and kidney [3].

References

  1. Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis. Le Stunff, H., Mikami, A., Giussani, P., Hobson, J.P., Jolly, P.S., Milstien, S., Spiegel, S. J. Biol. Chem. (2004) [Pubmed]
  2. Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. Yamanaka, M., Shegogue, D., Pei, H., Bu, S., Bielawska, A., Bielawski, J., Pettus, B., Hannun, Y.A., Obeid, L., Trojanowska, M. J. Biol. Chem. (2004) [Pubmed]
  3. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. Johnson, K.R., Johnson, K.Y., Becker, K.P., Bielawski, J., Mao, C., Obeid, L.M. J. Biol. Chem. (2003) [Pubmed]
  4. Transcript profiling of pacifastin-like peptide precursors in crowd- and isolated-reared desert locusts. Simonet, G., Claeys, I., Breugelmans, B., Van Soest, S., De Loof, A., Vanden Broeck, J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  5. A fractal analysis of analyte-estrogen receptor binding and dissociation kinetics using biosensors: environmental effects. Butala, H.D., Sadana, A. Journal of colloid and interface science. (2003) [Pubmed]
  6. An examination of MS candidate genes identified as differentially regulated in multiple sclerosis plaque tissue, using absolute and comparative real-time Q-PCR analysis. Tajouri, L., Mellick, A.S., Tourtellotte, A., Nagra, R.M., Griffiths, L.R. Brain Res. Brain Res. Protoc. (2005) [Pubmed]
  7. Sphingosine-1-phosphate phosphatases. Mandala, S.M. Prostaglandins Other Lipid Mediat. (2001) [Pubmed]
 
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