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Gene Review

NRAMP3  -  metal transporter Nramp3

Arabidopsis thaliana

Synonyms: ATNRAMP3, METAL TRANSPORTER NRAMP3, T20D16.22, T20D16_22, natural resistance-associated macrophage protein 3
 
 
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Disease relevance of NRAMP3

 

High impact information on NRAMP3

  • In plants, AtNRAMP3 and AtNRAMP4 are induced under Fe deficiency [2].
  • In addition, overexpression of AtNRAMP3 downregulates the expression of the primary Fe uptake transporter IRT1 and of the root ferric chelate reductase FRO2 [3].
  • Expression of AtNRAMP3::GFP fusion protein in onion cells or Arabidopsis protoplasts shows that AtNRAMP3 protein localizes to the vacuolar membrane [3].
  • Upon Fe starvation, AtNRAMP3 disruption leads to increased accumulation of manganese (Mn) and zinc (Zn) in the roots, whereas AtNRAMP3 overexpression downregulates Mn accumulation [3].
  • We identify eight genes which consistently show greater expression in accumulator phenotypes in both roots and shoots, including two metal transporter genes (NRAMP3 and ZIP6), and cytoplasmic aconitase, a gene involved in iron homeostasis in mammals [4].
 

Biological context of NRAMP3

  • The similitude of AtNRAMP3 and AtNRAMP4 expression patterns and their common targeting to the vacuole, together with the lack of obvious phenotype in nramp3-1 and nramp4-1 single knockout mutants, suggested a functional redundancy [2].

References

  1. Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes. Thomine, S., Wang, R., Ward, J.M., Crawford, N.M., Schroeder, J.I. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Mobilization of vacuolar iron by AtNRAMP3 and AtNRAMP4 is essential for seed germination on low iron. Lanquar, V., Lelièvre, F., Bolte, S., Hamès, C., Alcon, C., Neumann, D., Vansuyt, G., Curie, C., Schröder, A., Krämer, U., Barbier-Brygoo, H., Thomine, S. EMBO J. (2005) [Pubmed]
  3. AtNRAMP3, a multispecific vacuolar metal transporter involved in plant responses to iron deficiency. Thomine, S., Lelièvre, F., Debarbieux, E., Schroeder, J.I., Barbier-Brygoo, H. Plant J. (2003) [Pubmed]
  4. Comparison of gene expression in segregating families identifies genes and genomic regions involved in a novel adaptation, zinc hyperaccumulation. Filatov, V., Dowdle, J., Smirnoff, N., Ford-Lloyd, B., Newbury, H.J., Macnair, M.R. Mol. Ecol. (2006) [Pubmed]
 
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