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DOCK8  -  dedicator of cytokinesis 8

Homo sapiens

 
 
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Disease relevance of DOCK8

 

High impact information on DOCK8

  • The monoallelic expression was restricted to the ANKRD15 gene, whereas biallelic expression was found in the DOCK8 gene, which resides at the telomeric side of the deletion [2].
  • Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology [3].
  • Transient transfection of a C-terminal fragment of DOCK8 resulted in the formation of vesicular structures [3].
  • Immunofluorescence staining showed that transiently transfected HA-tagged DOCK8, as well as endogenous DOCK8, was present at the cell edges in areas undergoing lamellipodia formation [3].
  • 5-Aza-2'-deoxy-cytidine and/or Trichostatin A treatments induced DOCK8 expression in lung cancer cell lines with reduced DOCK8 expression [1].
 

Biological context of DOCK8

 

Anatomical context of DOCK8

  • DOCK8 was expressed in a variety of human organs, including the lungs, and was also expressed in type II alveolar, bronchiolar epithelial and bronchial epithelial cells, which are considered as being progenitors for lung cancer cells [1].

References

  1. Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer. Takahashi, K., Kohno, T., Ajima, R., Sasaki, H., Minna, J.D., Fujiwara, T., Tanaka, N., Yokota, J. Int. J. Oncol. (2006) [Pubmed]
  2. Deletion of the ANKRD15 gene at 9p24.3 causes parent-of-origin-dependent inheritance of familial cerebral palsy. Lerer, I., Sagi, M., Meiner, V., Cohen, T., Zlotogora, J., Abeliovich, D. Hum. Mol. Genet. (2005) [Pubmed]
  3. Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology. Ruusala, A., Aspenström, P. FEBS Lett. (2004) [Pubmed]
 
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