Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ZNRF1 - zinc and ring finger 1, E3 ubiquitin...

Homo sapiens

Synonyms: DKFZp434E229, E3 ubiquitin-protein ligase ZNRF1, FLJ14846, NIN283, Nerve injury-induced gene 283 protein, ...

Araki, T. et al.

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High impact information on ZNRF1

Here we describe the identification of a closely related protein, ZNRF2, thus defining a novel family of ZNRF E3 ubiquitin ligases [1].
We previously identified ZNRF1/nin283, a protein with a unique, evolutionarily conserved C-terminal domain containing a juxtaposed zinc finger/RING finger combination [1].
Mutant ZNRF proteins with a disrupted RING finger, a domain necessary for their E3 function, can each inhibit Ca2+-dependent exocytosis in PC12 cells [1].

Anatomical context of ZNRF1

In neurons, ZNRF proteins are located in different compartments within the presynaptic terminal: ZNRF1 is associated with synaptic vesicle membranes, whereas ZNRF2 is present in presynaptic plasma membranes [1].

References

ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. Araki, T., Milbrandt, J. J. Neurosci. (2003) [Pubmed]

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