Gene Review:
ALG2
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ALG2, alpha-1,3/1,6-mannosyltransferase
Homo sapiens
Synonyms:
Alpha-1,3/1,6-mannosyltransferase ALG2, Asparagine-linked glycosylation protein 2 homolog, CDGIi, FLJ14511, GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase, ...
ALG2 encodes an alpha1,3 mannosyltransferase involved in the earliest steps of N-glycosylation, the synthesis of the Dolichyl-linked N-glycan precursor.
In the literature, it is frequently confused with ALG-2, Apoptosis Linked Gene 2 (also known as PDCD6) .
Disease relevance of ALG2
ALG2 is involved in Congenital Disorder of Glycosylation Ii ( )
- A cell-membrane fraction isolated from Escherichia coli overexpressing thioredoxin-tagged Alg2 was used to demonstrate that this enzyme actually carries out an alpha1,3-mannosylation, followed by an alpha1,6-mannosylation, to form the first branched pentasaccharide intermediate of the pathway [1].
High impact information on ALG2
- Expression of wild type but not of mutant hALG2 cDNA restored the mannosyltransferase activity and the biosynthesis of dolichol-linked oligosaccharides both in patient fibroblasts and in the alg2-1 yeast cells. hALG2 was shown to act as an alpha1,3-mannosyltransferase [2].
- Deficiency of GDP-Man:Man1GlcNAc2-PP-dolichol mannosyltransferase (hALG2), is the cause of a new type of congenital disorders of glycosylation (CDG) designated CDG-Ii [2].
Biological context of ALG2
(all the entries were related to ALG-2, aka PDCD6)
Anatomical context of ALG2
(all the entries were related to ALG-2, aka PDCD6)
Associations of ALG2 with chemical compounds
Analytical, diagnostic and therapeutic context of ALG2
(all the entries were related to ALG-2, aka PDCD6)
References