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CSE4  -  Cse4p

Saccharomyces cerevisiae S288c

Synonyms: CENP-A homolog, CSL2, Chromosome segregation protein 4, Histone H3-like centromeric protein CSE4, YKL049C, ...
 
 
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High impact information on CSE4

 

Biological context of CSE4

  • The wild-type gene, CSE4, is essential for cell division and encodes a protein containing a domain that is 64% identical to the highly conserved chromatin protein, histone H3 [4].
  • High-copy CSE4, encoding an H3 variant related to the mammalian CENP-A kinetochore antigen, was found to suppress the temperature sensitivity of the mutant without suppressing the Spt- transcription defect [5].
  • Stoler et al. have recently reported the cloning of an essential gene CSE4, mutations in which cause chromosome nondisjunction of a marked chromosome bearing a centromere DNA mutation [6].
  • CSE4 genetically interacts with the Saccharomyces cerevisiae centromere DNA elements CDE I and CDE II but not CDE III. Implications for the path of the centromere dna around a cse4p variant nucleosome [7].
  • The CEN-specific histone, Cse4p, is one of a few stable kinetochore components and remains associated with CEN DNA throughout mitosis [8].
 

Associations of CSE4 with chemical compounds

  • Because mutation of all Cse4 lysine residues did not completely stabilize the protein, we isolated a dominant lethal mutant, CSE4-351, that was stable [9].
 

Other interactions of CSE4

  • A lack of functional Cse4p disrupts the remodeling of STB chromatin by the RSC2 complex, negates Rep2p binding and cohesin assembly at STB, and causes plasmid missegregation [10].
 

Analytical, diagnostic and therapeutic context of CSE4

References

  1. Identification of cohesin association sites at centromeres and along chromosome arms. Tanaka, T., Cosma, M.P., Wirth, K., Nasmyth, K. Cell (1999) [Pubmed]
  2. Cse4p is a component of the core centromere of Saccharomyces cerevisiae. Meluh, P.B., Yang, P., Glowczewski, L., Koshland, D., Smith, M.M. Cell (1998) [Pubmed]
  3. Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore. Measday, V., Hailey, D.W., Pot, I., Givan, S.A., Hyland, K.M., Cagney, G., Fields, S., Davis, T.N., Hieter, P. Genes Dev. (2002) [Pubmed]
  4. A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis. Stoler, S., Keith, K.C., Curnick, K.E., Fitzgerald-Hayes, M. Genes Dev. (1995) [Pubmed]
  5. A novel histone H4 mutant defective in nuclear division and mitotic chromosome transmission. Smith, M.M., Yang, P., Santisteban, M.S., Boone, P.W., Goldstein, A.T., Megee, P.C. Mol. Cell. Biol. (1996) [Pubmed]
  6. Is there a unique form of chromatin at the Saccharomyces cerevisiae centromeres? Basrai, M.A., Hieter, P. Bioessays (1995) [Pubmed]
  7. CSE4 genetically interacts with the Saccharomyces cerevisiae centromere DNA elements CDE I and CDE II but not CDE III. Implications for the path of the centromere dna around a cse4p variant nucleosome. Keith, K.C., Fitzgerald-Hayes, M. Genetics (2000) [Pubmed]
  8. The kinetochore protein Ndc10p is required for spindle stability and cytokinesis in yeast. Bouck, D.C., Bloom, K.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. Proteolysis contributes to the exclusive centromere localization of the yeast Cse4/CENP-A histone H3 variant. Collins, K.A., Furuyama, S., Biggins, S. Curr. Biol. (2004) [Pubmed]
  10. The centromere-specific histone variant Cse4p (CENP-A) is essential for functional chromatin architecture at the yeast 2-{micro}m circle partitioning locus and promotes equal plasmid segregation. Hajra, S., Ghosh, S.K., Jayaram, M. J. Cell Biol. (2006) [Pubmed]
 
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