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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

INTS4  -  integrator complex subunit 4

Homo sapiens

Synonyms: INT4, Int4, Integrator complex subunit 4, MGC16733, MST093, ...
 
 
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Disease relevance of INTS4

  • RESULTS: Heterozygotes at intron 4 (469 + 14G/C) [INT4], codon 543 in exon 15 (D543N), and 3' untranslated region (3'UTR) were observed at significantly higher frequencies in patients with NTM lung disease than in control subjects [1].
 

High impact information on INTS4

  • Subjects who were heterozygous for two NRAMP1 polymorphisms in INT4 and D543N were particularly overrepresented among those with NTM lung disease, compared with those with the most common NRAMP1 genotype (OR, 10.88, 95% CI, 1.18 to 100.45; p = 0.035) [1].
  • Genetic polymorphisms of VDR gene (TaqI and FokI) and NRAMP1 gene (INT4, D543N and 3'UTR) were analysed using PCR and RFLP [2].

References

  1. NRAMP1 gene polymorphism and susceptibility to nontuberculous mycobacterial lung diseases. Koh, W.J., Kwon, O.J., Kim, E.J., Lee, K.S., Ki, C.S., Kim, J.W. Chest (2005) [Pubmed]
  2. VDR and NRAMP1 gene polymorphisms in susceptibility to pulmonary tuberculosis among the Chinese Han population: a case-control study. Liu, W., Cao, W.C., Zhang, C.Y., Tian, L., Wu, X.M., Habbema, J.D., Zhao, Q.M., Zhang, P.H., Xin, Z.T., Li, C.Z., Yang, H. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. (2004) [Pubmed]
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