Disease relevance of BZRAP1

• RBP-1 peptide antigens may be of clinical significance as a potential peptide vaccine against human breast cancer [1].
• Retinoblastoma binding protein 1 (RBP-1) is a 143-kDa nuclear phosphoprotein that promotes cell growth by inhibiting the product of retinoblastoma tumour suppressor gene (pRB) [1].

High impact information on BZRAP1

• Cytotoxic T lymphocytes that recognize decameric peptide sequences of retinoblastoma binding protein 1 (RBP-1) associated with human breast cancer [1].
• By solid-phase synthetic approach, the core sequences recognized by two of these monoclonal antibodies were identified to amino acid sequences 45-51 and 128-131 of the primary amino acid sequence of hRBP [2].

Anatomical context of BZRAP1

• In the present study, we demonstrate that human T-cells stimulated with RBP-1 decameric peptides containing KASIFLK can kill human breast cancer cells [1].

References