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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

aer  -  fused signal transducer for aerotaxis...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3062, JW3043, air, yqjJ
 
 
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Disease relevance of aer

  • An flhD::Kan insertion and an aer deletion were independently introduced into two Escherichia coli K-12 strains, and the effects upon gene regulation were investigated [1].
  • An aerotaxis gene, aer, was cloned from Pseudomonas putida PRS2000 [2].
 

High impact information on aer

  • A double mutant deficient in aer and tsr, which codes for the serine chemoreceptor, was negative for aerotaxis, redox taxis, and glycerol taxis, each of which requires the proton motive force and/or electron transport system for signaling [3].
  • Primers targeted a 209-bp fragment of the aer gene coding for the beta-hemolysin and detected template DNA only in the PCR using nucleic acid (NA) from hemolytic strains of A. hydrophila which were also cytotoxic to Vero and CHO cells and enterotoxic in suckling-mouse assays [4].
 

Other interactions of aer

References

  1. FlhD/FlhC is a regulator of anaerobic respiration and the Entner-Doudoroff pathway through induction of the methyl-accepting chemotaxis protein Aer. Prüss, B.M., Campbell, J.W., Van Dyk, T.K., Zhu, C., Kogan, Y., Matsumura, P. J. Bacteriol. (2003) [Pubmed]
  2. An aerotaxis transducer gene from Pseudomonas putida. Nichols, N.N., Harwood, C.S. FEMS Microbiol. Lett. (2000) [Pubmed]
  3. The Aer protein and the serine chemoreceptor Tsr independently sense intracellular energy levels and transduce oxygen, redox, and energy signals for Escherichia coli behavior. Rebbapragada, A., Johnson, M.S., Harding, G.P., Zuccarelli, A.J., Fletcher, H.M., Zhulin, I.B., Taylor, B.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Detection of the aerolysin gene in Aeromonas hydrophila by the polymerase chain reaction. Pollard, D.R., Johnson, W.M., Lior, H., Tyler, S.D., Rozee, K.R. J. Clin. Microbiol. (1990) [Pubmed]
  5. Differentiation between electron transport sensing and proton motive force sensing by the Aer and Tsr receptors for aerotaxis. Edwards, J.C., Johnson, M.S., Taylor, B.L. Mol. Microbiol. (2006) [Pubmed]
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