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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Influence of liposomal amphotericin B on CD8 T-cell function.

Liposomal amphotericin B was immunosuppressive on target cell lysis in vitro and on protection mediated by cytotoxic CD8 T cells in murine listeriosis. When dosages usually used for therapy in humans were compared, the immunosuppressive effect of 5 mg of liposomal amphotericin B/kg of body weight/day was similar to that of standard amphotericin B at 1 mg/kg/day, but a dosage of liposomal amphotericin B of 1 mg/kg/day was not suppressive in vivo.[1]

References

  1. Influence of liposomal amphotericin B on CD8 T-cell function. Kretschmar, M., Geginat, G., Bertsch, T., Walter, S., Hof, H., Nichterlein, T. Antimicrob. Agents Chemother. (2001) [Pubmed]
 
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