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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Secrets of a secretase: N-cadherin proteolysis regulates CBP function.

Presenilin (PS-1) is part of the protease gamma-secretase that cleaves the membrane proteins APP and Notch. In this issue of Cell, Marambaud et al. report that PS-1 cleaves the cell adhesion molecule N-cadherin, releasing a C-terminal fragment that promotes degradation of the transcriptional coactivator CBP. Mutations in PS-1 associated with Alzheimer's disease interfere with CBP proteolysis, leading to abnormal transcription.[1]


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