- Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response. Panitsas, F.P., Theodoropoulou, M., Kouraklis, A., Karakantza, M., Theodorou, G.L., Zoumbos, N.C., Maniatis, A., Mouzaki, A. Blood (2004)