Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Rosenmann, H. et al.

Rosenmann, Meiner, Kahana, Aladjem, Friedman, Ben-Yehuda, Grenader, Wertman, Abramsky,

The Fas promoter polymorphism at position -670 is not associated with late-onset sporadic Alzheimer's disease.

The Fas antigen is a cell surface receptor-mediating cell apoptosis. Recent studies have demonstrated that Fas-associated apoptosis is involved in the pathogenesis of Alzheimer's disease (AD). Moreover, the Fas gene is located on chromosome 10q24.1, a region of linkage to late-onset AD (LOAD). These two criteria, pathobiological and positional, make the Fas antigen an interesting candidate for an association with AD. We performed a case-control association study between the common A/G polymorphism at position -670 in the Fas gene (TNFSRF6) promoter and sporadic AD in Jews, investigating whether this locus acts as a risk factor or whether it has a modifying effect. An association has recently been detected by Feuk et al. in the Scottish population between this locus and the risk of early-onset AD (EOAD), but not of LOAD. In agreement with Feuk et al., we found no association between this locus and the risk of LOAD (n = 86). However, in our small sample of patients with EOAD (n = 19), no association was found either. No interactive effect was found between the Fas promoter polymorphism at position -670 and the known risk factor of LOAD, apolipoprotein E epsilon4, and no association was detected with disease progression. These findings show no evidence for an association between the Fas promoter polymorphism at position -670 and AD in our population.[1]

References

The Fas promoter polymorphism at position -670 is not associated with late-onset sporadic Alzheimer's disease. Rosenmann, H., Meiner, Z., Kahana, E., Aladjem, Z., Friedman, G., Ben-Yehuda, A., Grenader, T., Wertman, E., Abramsky, O. Dementia and geriatric cognitive disorders. (2004) [Pubmed]

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