- JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells. Shi, X., Franko, B., Frantz, C., Amin, H.M., Lai, R. Br. J. Haematol. (2006)