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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A rationale for the treatment of metastatic neuroblastoma.

In developing a chemotherapeutic program for children with disseminated neuroblastoma, we established three human neuroblastoma lines in cell culture to study the effects of dibutyryl cyclic AMP, papaverine, 5-trifluoromethyl-2'-deoxyuridine, and cyclophosphamide on cell growth, biochemical behavior, and morphology. Based upon our studies, a clinical treatment program was designed. We have treated 15 patients with disseminated neuroblastoma and have established the optimum dose range and sequence of these drugs. Early results were promising; plans for continuation of clinical and experimental studies were discussed.[1]

References

  1. A rationale for the treatment of metastatic neuroblastoma. Helson, L., Helson, C., Peterson, R.F., Das, S.K. J. Natl. Cancer Inst. (1976) [Pubmed]
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