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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Receptor for the cell binding site of discoidin I.

Discoidin I, a developmentally regulated lectin in Dictyostelium discoideum, has been implicated in cell-substratum adhesion and ordered cell migration during aggregation. This depends on the cell binding site of discoidin I, which is distinct from its carbohydrate binding site. We have isolated a receptor for the cell binding site by affinity chromatography. The receptor binds immobilized discoidin I in the presence of 0.3 M galactose and can be eluted with gly-arg-gly-asp-his-asp, a synthetic peptide the sequence of which is found in discoidin I, and which blocks cell migration into aggregates. The receptor is a developmentally regulated cell-surface glycoprotein of apparent Mr approximately 67,000. Univalent antibodies specific for this glycoprotein block aggregation.[1]


  1. Receptor for the cell binding site of discoidin I. Gabius, H.J., Springer, W.R., Barondes, S.H. Cell (1985) [Pubmed]
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