- Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families. Van Broeckhoven, C., Genthe, A.M., Vandenberghe, A., Horsthemke, B., Backhovens, H., Raeymaekers, P., Van Hul, W., Wehnert, A., Gheuens, J., Cras, P. Nature (1987)