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Tainsky, M.A. et al.

Human recipient cell for oncogene transfection studies.

We used human oncogene DNA to transform the nontumorigenic, revertant, human osteosarcoma cell line HOS TE-85 clone 5 (ATCC CRL 1543) to tumorigenicity in athymic nude mice with latency periods as short as 3 weeks. These cells were also transformed by genetic markers in genomic DNA samples. Because of their low rate of spontaneous tumor formation and the simplicity of culturing them, HOS cells provide a human cell alternative to NIH 3T3 murine fibroblasts for oncogene transfection studies.[1]

References

Human recipient cell for oncogene transfection studies. Tainsky, M.A., Shamanski, F.L., Blair, D., Vande Woude, G. Mol. Cell. Biol. (1987) [Pubmed]

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