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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Human recipient cell for oncogene transfection studies.

We used human oncogene DNA to transform the nontumorigenic, revertant, human osteosarcoma cell line HOS TE-85 clone 5 (ATCC CRL 1543) to tumorigenicity in athymic nude mice with latency periods as short as 3 weeks. These cells were also transformed by genetic markers in genomic DNA samples. Because of their low rate of spontaneous tumor formation and the simplicity of culturing them, HOS cells provide a human cell alternative to NIH 3T3 murine fibroblasts for oncogene transfection studies.[1]


  1. Human recipient cell for oncogene transfection studies. Tainsky, M.A., Shamanski, F.L., Blair, D., Vande Woude, G. Mol. Cell. Biol. (1987) [Pubmed]
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