- A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Frosst, P., Blom, H.J., Milos, R., Goyette, P., Sheppard, C.A., Matthews, R.G., Boers, G.J., den Heijer, M., Kluijtmans, L.A., van den Heuvel, L.P. Nat. Genet. (1995)