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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

p300/MDM2 complexes participate in MDM2- mediated p53 degradation.

Control of p53 turnover is critical to p53 function. E1A binding to p300/ CBP translates into enhanced p53 stability, implying that these coactivator proteins normally operate in p53 turnover control. In this regard, the p300 C/H1 region serves as a specific in vivo binding site for both p53 and MDM2, a naturally occurring p53 destabilizer. Moreover, most of the endogenous MDM2 is bound to p300, and genetic analysis implies that specific interactions of p53 and MDM2 with p300 C/H1 are important steps in the MDM2-directed turnover of p53. A specific role for p300 in endogenous p53 degradation is underscored by the p53-stabilizing effect of overproducing the p300 C/H1 domain. Taken together, the data indicate that specific interactions between p300/ CBP C/H1, p53, and MDM2 are intimately involved in the MDM2- mediated control of p53 abundance.[1]


  1. p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Grossman, S.R., Perez, M., Kung, A.L., Joseph, M., Mansur, C., Xiao, Z.X., Kumar, S., Howley, P.M., Livingston, D.M. Mol. Cell (1998) [Pubmed]
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