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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 276 documents. Results 1 - 10.

Homo sapiens
Gene: ... . These findings collectively suggest that the mTOR pathway is positively regulated by Notch in T- ALL cells. High... compared with the wild- type protein, whereas all other mutations at this site, including mimics...- sensing pathway governed by mammalian target- of- rapamycin( mTOR). Modulation of hypoxia- inducible... / Synonyms: Serine/threonine-protein kinase mTOR; mTOR
Mus musculus
Gene: ... activation of mTOR through upstream regulator Akt also increased ABI in colon cancer cells. High ABI in all...Disease relevance of Frap1 Energy depletion and hypoxia result in mTOR inhibition. Several studies have implicated the mammalian target of rapamycin( mTOR) signaling pathway in obesity. Rapamycin... / Synonyms: Serine/threonine-protein kinase mTOR; mTOR
Rattus norvegicus
Gene: ... . Furthermore, rapamycin, a selective blocker of mTOR, blocked hypertrophy in all models tested, without causing...Disease relevance of Frap1 The tuberous sclerosis complex- mammalian target of rapamycin( TSC- mTOR.... However, it is still unclear whether activation of the mTOR pathway is increased in obesity... / Synonyms: Serine/threonine-protein kinase mTOR; mTOR
Drosophila melanogaster
Gene: ... High impact information on Mtor The TPR snap helix: a novel protein repeat motif from mitosis.... Biological context of Mtor Megator, an essential coiled- coil protein that localizes to the putative spindle...- containing protein whose function is essential for embryonic development. Anatomical context of Mtor... / Synonyms: MTOR
Homo sapiens
Gene: ... protein of mTOR) complex and thus do not perturb all mTOR functions. Hypersensitivity pneumonitis... on Ser636/ 639. A point mutation of the TOS motif also eliminates all in vitro mTOR- catalyzed 4E- BP1...Disease relevance of KIAA1303 Signaling mediated by the mammalian target of rapamycin kinase( mTOR... / Synonyms: Regulatory-associated protein of mTOR
Homo sapiens
Gene: ... Disease relevance of RICTOR Signaling mediated by the mammalian target of rapamycin kinase( mTOR) is activated during human cytomegalovirus( HCMV) infection. mTOR is found in two complexes differing... results in embryonic lethality and ablates Akt phosphorylation. The distinct complex of mTOR, mLST8... / Synonyms: Rapamycin-insensitive companion of mTOR
Pan troglodytes
Gene: ... High impact information on FRAP1 ANGPTL7 gene at human chromosome 1p36. 22 was located within intron 28 of FRAP1 gene encoding mTOR protein....
Mus musculus
Gene: ... , we conclude that mTOR complexed to RICTOR is the Ser- 473 kinase in 3T3- L1 adipocytes. Small... directed against mTOR or RICTOR had phosphatidylinositol 3, 4, 5- trisphosphate- stimulated Ser- 473... / Synonyms: Rapamycin-insensitive companion of mTOR
Homo sapiens
Mus musculus
Gene: ... High impact information on 4932417H02Rik Thus, raptor is an essential scaffold for the mTOR- catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo. Rapamycin or amino acid withdrawal increases, whereas insulin strongly inhibits, the recovery of 4EBP1 and raptor on 7- methyl- GTP Sepharose... / Synonyms: Regulatory-associated protein of mTOR


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