Gene Review:
MTOR - mechanistic target of rapamycin...
Homo sapiens
Synonyms:
FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, FLJ44809, FRAP, FRAP1, ...
- Inhibition of epidermal growth factor receptor signaling protects human malignant glioma cells from hypoxia-induced cell death. Steinbach, J.P., Klumpp, A., Wolburg, H., Weller, M. Cancer Res. (2004)
- Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Zhong, H., Chiles, K., Feldser, D., Laughner, E., Hanrahan, C., Georgescu, M.M., Simons, J.W., Semenza, G.L. Cancer Res. (2000)
- Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Choi, J., Chen, J., Schreiber, S.L., Clardy, J. Science (1996)
- Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation. Castedo, M., Ferri, K.F., Blanco, J., Roumier, T., Larochette, N., Barretina, J., Amendola, A., Nardacci, R., Métivier, D., Este, J.A., Piacentini, M., Kroemer, G. J. Exp. Med. (2001)
- Isolation of receptor-ligand pairs by capture of long-lived multivalent interaction complexes. de Wildt, R.M., Tomlinson, I.M., Ong, J.L., Holliger, P. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia. Chan, S.M., Weng, A.P., Tibshirani, R., Aster, J.C., Utz, P.J. Blood (2007)
- Golgi membranes remain segregated from the endoplasmic reticulum during mitosis in mammalian cells. Pecot, M.Y., Malhotra, V. Cell (2004)
- mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Kim, D.H., Sarbassov, D.D., Ali, S.M., King, J.E., Latek, R.R., Erdjument-Bromage, H., Tempst, P., Sabatini, D.M. Cell (2002)
- DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Hartley, K.O., Gell, D., Smith, G.C., Zhang, H., Divecha, N., Connelly, M.A., Admon, A., Lees-Miller, S.P., Anderson, C.W., Jackson, S.P. Cell (1995)
- Control of p70 s6 kinase by kinase activity of FRAP in vivo. Brown, E.J., Beal, P.A., Keith, C.T., Chen, J., Shin, T.B., Schreiber, S.L. Nature (1995)
- Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Gingras, A.C., Gygi, S.P., Raught, B., Polakiewicz, R.D., Abraham, R.T., Hoekstra, M.F., Aebersold, R., Sonenberg, N. Genes Dev. (1999)
- 4-Hydroxy estradiol but not 2-hydroxy estradiol induces expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor A through phosphatidylinositol 3-kinase/Akt/FRAP pathway in OVCAR-3 and A2780-CP70 human ovarian carcinoma cells. Gao, N., Nester, R.A., Sarkar, M.A. Toxicol. Appl. Pharmacol. (2004)
- Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Dan, H.C., Cooper, M.J., Cogswell, P.C., Duncan, J.A., Ting, J.P., Baldwin, A.S. Genes Dev. (2008)
- Comparative integromics on Angiopoietin family members. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2006)
- RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Burnett, P.E., Barrow, R.K., Cohen, N.A., Snyder, S.H., Sabatini, D.M. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation. Kim, J.E., Chen, J. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein. Peterson, R.T., Desai, B.N., Hardwick, J.S., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling. Pirola, L., Zvelebil, M.J., Bulgarelli-Leva, G., Van Obberghen, E., Waterfield, M.D., Wymann, M.P. J. Biol. Chem. (2001)
- Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts. Brenneisen, P., Wenk, J., Wlaschek, M., Krieg, T., Scharffetter-Kochanek, K. J. Biol. Chem. (2000)
- Factors Controlling Fibroblast Growth Factor Receptor-1's Cytoplasmic Trafficking and Its Regulation as Revealed by FRAP Analysis. Dunham-Ems, S.M., Pudavar, H.E., Myers, J.M., Maher, P.A., Prasad, P.N., Stachowiak, M.K. Mol. Biol. Cell (2006)
- FKBP12-rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus. Drenan, R.M., Liu, X., Bertram, P.G., Zheng, X.F. J. Biol. Chem. (2004)
- Molecular cloning and expression analysis of five novel genes in chromosome 1p36. Onyango, P., Lubyova, B., Gardellin, P., Kurzbauer, R., Weith, A. Genomics (1998)
- FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions. Peterson, R.T., Beal, P.A., Comb, M.J., Schreiber, S.L. J. Biol. Chem. (2000)
- Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation. Hartman, M.E., Villela-Bach, M., Chen, J., Freund, G.G. Biochem. Biophys. Res. Commun. (2001)
- Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Chen, J., Zheng, X.F., Brown, E.J., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells. Grewe, M., Gansauge, F., Schmid, R.M., Adler, G., Seufferlein, T. Cancer Res. (1999)
- HLA class I antibody-mediated endothelial cell proliferation via the mTOR pathway. Jindra, P.T., Jin, Y.P., Rozengurt, E., Reed, E.F. J. Immunol. (2008)
- A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Brown, E.J., Albers, M.W., Shin, T.B., Ichikawa, K., Keith, C.T., Lane, W.S., Schreiber, S.L. Nature (1994)
- A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation. Gonzalez-Garcia, A., Garrido, E., Hernandez, C., Alvarez, B., Jimenez, C., Cantrell, D.A., Pullen, N., Carrera, A.C. J. Biol. Chem. (2002)
- Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Yokogami, K., Wakisaka, S., Avruch, J., Reeves, S.A. Curr. Biol. (2000)
- Ionizing radiation enhances double-strand-break repair in rapamycin-treated ataxia telangiectasia lymphoblasts. Sikpi, M.O., Wang, Y. Int. J. Radiat. Biol. (2000)
- The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. Vassilev, A., Yamauchi, J., Kotani, T., Prives, C., Avantaggiati, M.L., Qin, J., Nakatani, Y. Mol. Cell (1998)
- Monitoring protein-protein interactions in intact eukaryotic cells by beta-galactosidase complementation. Rossi, F., Charlton, C.A., Blau, H.M. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Assignment of the human FKBP12-rapamycin-associated protein (FRAP) gene to chromosome 1p36 by fluorescence in situ hybridization. Moore, P.A., Rosen, C.A., Carter, K.C. Genomics (1996)
- Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane. Rotblat, B., Prior, I.A., Muncke, C., Parton, R.G., Kloog, Y., Henis, Y.I., Hancock, J.F. Mol. Cell. Biol. (2004)
- Photodynamic therapy on keloid fibroblasts in tissue-engineered keratinocyte-fibroblast co-culture. Chiu, L.L., Sun, C.H., Yeh, A.T., Torkian, B., Karamzadeh, A., Tromberg, B., Wong, B.J. Lasers in surgery and medicine. (2005)