Your search matched a total of 105 documents. Results 1 - 10.
Homo sapiens
Gene: ... Disease relevance of PDK1 To further validate this observation, we used small interfering RNA oligonucleotides to selectively knock down PDK1 or Akt1 expression in MCF7 human breast cancer cells. Mammary fat pad isografts of PDK1- expressing cells produced invasive adenocarcinomas. Recently, increased PDK...
Caenorhabditis elegans
Gene: ... High impact information on pdk- 1 The activating pdk- 1 mutation is located in a conserved region of the kinase domain; the equivalent amino acid substitution in human PDK1 activates its kinase activity toward mammalian Akt/ PKB. Two mutations were gain- of- function alleles in the genes, akt- 1 and pdk- 1, encoding...
Drosophila melanogaster
Gene: ... , but requires dPDK1. More striking, despite dPKB- dPI( 3) K- independence, dS6K activity is dependent on the Drosophila homologue of the phosphoinositide- dependent protein kinase 1, dPDK1, demonstrating that both dPDK... )- independent. This functional interaction between dPDK- 1 and Dakt1 was further confirmed through genetic... / Synonyms: PDK-1; PDK1; PDK1/Pk61C
Arabidopsis thaliana
Gene: ... located C- terminal of the catalytic domain in the AGC kinase. AtPDK1 is ubiquitously expressed in all...Disease relevance of PDK1 We now show that AtPDK1, expressed in E. coli as a recombinant protein, undergoes autophosphorylation at several sites. High impact information on PDK1 Plant hormones, auxin...
Rattus norvegicus
Gene: ... Disease relevance of Pdk1 Selective modification of the pyruvate dehydrogenase kinase isoform profile in skeletal muscle in hyperthyroidism: implications for the regulatory impact of glucose on fatty acid oxidation. High impact information on Pdk1 Selective modification of pyruvate dehydrogenase kinase...
Homo sapiens
Gene: ... oligonucleotides to selectively knock down PDK1 or Akt1 expression in MCF7 human breast cancer cells. Structure... for their potency in inhibiting PDK- 1 kinase activity and in inducing apoptosis in PC- 3 prostate cancer cells... in the human colon cancer HT- 29 cell line. We cloned a full- length pdk- 1 cDNA from a human brain c... / Synonyms: PDK1; hPDK1
Mus musculus
Gene: ... - phosphoinositide- dependent protein kinase( PDK )- 1 to recruit and phosphorylate protein kinase C( PKC )- zeta, a negative regulator of IGF- 1 signaling. The mPDK1 (-/-) animals had thinner ventricular walls, enlarged atria and right ventricles. Moreover, mPDK1 (-/-) muscle mass was markedly reduced due to a reduction... / Synonyms: Pdk1; mPDK1
Chemical compound: ... through the Ser/ Thr protein kinases PDK1 and Akt. The 3- phosphorylated inositol lipids fulfill roles... All strains containing suppressor mutations in RPB1 and RPB2 have reduced transcription of the INO1...
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Steven Johnsen and Donald R. Forsdyke and Kehinde Ross and Andrew Perry and Jonathan Eisen and A. Shimabukuro-Vornhagen and Giuseppe Rotondo and Gordon Laurie and Berkley Lynch and Kung-Hao Liang and Matthias Gstaiger and Thomas Pfeiffer and Marta Ramirez and Grant MacGregor and Jingyu Li and Fedik Rahimov and M El Gizouli and Marta Ramirez Gaite and Oswaldo Ribeiro-filho and Ralf Weigel and Bjoern Hamberger and Alexander Kanitz and Andreas Zankl and Chunming Ding and Maruf Yunus and Jonathan S. Berg and Michael Cariaso and Zakir Thomas and Monique Timberlake-Brady and LC Dore and Nan Shen and R. Eric Collins and Kuang-Mao Chiang and Brendan McMahon and John Chew and Wen-Ming Yang and Robert Hoffmann and J.B. Stewart and Manuela Cucerea and Ignacio García and William James and Thomas Kelder and Gregory Melahn and YINGDE ZHU and Andres Muro and Gabriel Santpere and Jeff Freilich and Junbin Qian and Steffen Poulsen and Eric Villard and Rafael Sidi and Grant Cramer and Chris Sander and Alexandre Chigaev and Florian Uhle and Carl Fulp and Andrew Brown and Xiaozhu Zhou and Corina Dutu and Hilary Spencer and david germano and Abbas Dehghan and Eung-ju PARK and Chris Sander and Albert Vilella and Miao Tian and Anjali Bheda and Michael Nevels and Jun Liu and D Delano and Chitose Taya and Soomi Cheong and David Kavanagh and Maha Karnoub and Hilmar Lapp and Christian Pallasch and Daniel Mietchen and Biju Balakrishnan and Keith Ashman and Juan Carlos Sobrino and Anshu Bhardwaj and Grzegorz Wickiel and Matthew Day and Anthony Sebastian and Vedran Katavic and Liang Long and Barry Wanner and Sarah Snelling and Fernando Montanes and Omobosede Fashedemi and Gustavo Cervantes and Manoj Kumar and Edward D Great and Paul Paukstelis and Roy Soetikno and Ana I Caño-Delgado and Minsoo Choi and Lei Wang and Brenda Riley and A Michelle Moon and Jon Moulton and Mahmoud Elshahawy and Meagan Gillespie and Banundari Rachmawati and Qian Han and Eric Danner and Xavier Fouillet and Madhusudhan Acharya and Brian Young and Chandra Sekhar Mukhopadhyay and shrawan bhattacharjee and Marieke van der Linden and cj hoban and Sandi Pniauskas and jackie gao and Metin Bilgin and Gillian L. Dalgliesh and Karl Wotton and Iveta Herichova and Yuji Morita and Marta Hernandez and Gregor Krings and Marco Briones and Tim D. Smith and Yiumo Michael Chan and Zhenyu Guo and Barry Barclay and Hong Wang and tarali chowdhury and Tilman Brummer and Nuno Faria and Tamir Ben David and Myles Axton and Yannick Fonseca and Francis Castets and Modesto Redrejo-Rodríguez and Bruce Herron and Toshio Fujita and Elena Puccetti and Zhang Zhang and John Osborne and Illes J Farkas and Fernando Andres and Phyllis Pugh and Jonathan Court and Tim Vickers and Nir Friedman and Holger Dick and Ya-Chen Liang and Jonathan Froehlich and Haitham Sobhy and David Abraham and Stephane Krief and Yaroslav Nikolaev and Qiping Feng and d gupta and R Thapar and Susan Wee and Michael Rehman and SOUMITRA GHOSH and Mohamed Eweida and Cedric Uytingco and Nie hongchuan and David Steenblock and Mark A. Kukucka and Zoli Fekete and Sergei Kozlov and Javier Jara and Osama Naguib and Felix Benninger and jean-marc lo-guidice and VASUDEVA BHAT and Anne O. Summers and Bjoern Titz and Anna Levine and Klas Udekwu and Robert Hoffmann
