Gene Review:
PDK1 - pyruvate dehydrogenase kinase, isozyme 1
Homo sapiens
Synonyms:
PDH kinase 1, PDHK1, Pyruvate dehydrogenase kinase isoform 1
- Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine. Liang, K., Lu, Y., Li, X., Zeng, X., Glazer, R.I., Mills, G.B., Fan, Z. Mol. Pharmacol. (2006)
- 3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases. Xie, Z., Yuan, H., Yin, Y., Zeng, X., Bai, R., Glazer, R.I. BMC Cancer (2006)
- Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects. Majer, M., Popov, K.M., Harris, R.A., Bogardus, C., Prochazka, M. Mol. Genet. Metab. (1998)
- Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase. Boulatnikov, I., Popov, K.M. Biochim. Biophys. Acta (2003)
- Cytotoxicity of a non-cyclooxygenase-2 inhibitory derivative of celecoxib in non-small-cell lung cancer A549 cells. Tong, Z., Wu, X., Chen, C.S., Kehrer, J.P. Lung Cancer (2006)
- PTEN and myotubularin: novel phosphoinositide phosphatases. Maehama, T., Taylor, G.S., Dixon, J.E. Annu. Rev. Biochem. (2001)
- Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4. Nirula, A., Ho, M., Phee, H., Roose, J., Weiss, A. J. Exp. Med. (2006)
- Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation. Biondi, R.M. Trends Biochem. Sci. (2004)
- PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1. Ivaska, J., Bosca, L., Parker, P.J. Nat. Cell Biol. (2003)
- Essential role of PDK1 in regulating endothelial cell migration. Primo, L., di Blasio, L., Roca, C., Droetto, S., Piva, R., Schaffhausen, B., Bussolino, F. J. Cell Biol. (2007)
- p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. Rane, M.J., Coxon, P.Y., Powell, D.W., Webster, R., Klein, J.B., Pierce, W., Ping, P., McLeish, K.R. J. Biol. Chem. (2001)
- Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein. Seong, H.A., Jung, H., Choi, H.S., Kim, K.T., Ha, H. J. Biol. Chem. (2005)
- HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Kim, J.W., Tchernyshyov, I., Semenza, G.L., Dang, C.V. Cell metabolism. (2006)
- Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha. Zeng, X., Xu, H., Glazer, R.I. Cancer Res. (2002)
- P2Y receptors activate MAPK/ERK through a pathway involving PI3K/PDK1/PKC-zeta in human vein endothelial cells. Montiel, M., de la Blanca, E.P., Jiménez, E. Cell. Physiol. Biochem. (2006)
- Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells. Abbot, E.L., McCormack, J.G., Reynet, C., Hassall, D.G., Buchan, K.W., Yeaman, S.J. FEBS J. (2005)
- Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites. Kolobova, E., Tuganova, A., Boulatnikov, I., Popov, K.M. Biochem. J. (2001)
- Kinase phosphorylation: Keeping it all in the family. Peterson, R.T., Schreiber, S.L. Curr. Biol. (1999)
- Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. Hughes, P.J., Zhao, Y., Chandraratna, R.A., Brown, G. J. Cell. Biochem. (2006)
- 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins. Seong, H.A., Jung, H., Kim, K.T., Ha, H. J. Biol. Chem. (2007)
- Human cytomegalovirus inhibits Akt-mediated eNOS activation through upregulating PTEN (phosphatase and tensin homolog deleted on chromosome 10). Shen, Y.H., Zhang, L., Utama, B., Wang, J., Gan, Y., Wang, X., Wang, J., Chen, L., Vercellotti, G.M., Coselli, J.S., Mehta, J.L., Wang, X.L. Cardiovasc. Res. (2006)
- Regulation of the mitogen-activated protein kinase signaling pathway by SHP2. Cunnick, J.M., Meng, S., Ren, Y., Desponts, C., Wang, H.G., Djeu, J.Y., Wu, J. J. Biol. Chem. (2002)
- Survival-signaling pathway as a promising target for cancer chemotherapy. Fujita, N., Tsuruo, T. Cancer Chemother. Pharmacol. (2003)
- 3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium. Budas, G.R., Sukhodub, A., Alessi, D.R., Jovanovi??, A. FASEB J. (2006)
- Allosteric activation of the protein kinase PDK1 with low molecular weight compounds. Engel, M., Hindie, V., Lopez-Garcia, L.A., Stroba, A., Schaeffer, F., Adrian, I., Imig, J., Idrissova, L., Nastainczyk, W., Zeuzem, S., Alzari, P.M., Hartmann, R.W., Piiper, A., Biondi, R.M. EMBO J. (2006)