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Karnam S. Murthy

Departments of Physiology and Medicine

Medical College of Virginia Campus

Virginia Commonwealth University




Name/email consistency: high



  • Departments of Physiology and Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA. 2000 - 2008


  1. Inhibitory phosphorylation of soluble guanylyl cyclase by muscarinic m2 receptors via Gbetagamma-dependent activation of c-Src kinase. Murthy, K.S. J. Pharmacol. Exp. Ther. (2008) [Pubmed]
  2. Signaling for contraction and relaxation in smooth muscle of the gut. Murthy, K.S. Annu. Rev. Physiol. (2006) [Pubmed]
  3. Modulation of soluble guanylate cyclase activity by phosphorylation. Murthy, K.S. Neurochem. Int. (2004) [Pubmed]
  4. Activation of PLC-delta1 by Gi/o-coupled receptor agonists. Murthy, K.S., Zhou, H., Huang, J., Pentyala, S.N. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  5. Selective phosphorylation of the IP3R-I in vivo by cGMP-dependent protein kinase in smooth muscle. Murthy, K.S., Zhou, H. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  6. Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway. Murthy, K.S., Zhou, H., Grider, J.R., Brautigan, D.L., Eto, M., Makhlouf, G.M. Biochem. J. (2003) [Pubmed]
  7. PKA-dependent activation of PDE3A and PDE4 and inhibition of adenylyl cyclase V/VI in smooth muscle. Murthy, K.S., Zhou, H., Makhlouf, G.M. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  8. cAMP inhibits IP(3)-dependent Ca(2+) release by preferential activation of cGMP-primed PKG. Murthy, K.S. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  9. Activation of phosphodiesterase 5 and inhibition of guanylate cyclase by cGMP-dependent protein kinase in smooth muscle. Murthy, K.S. Biochem. J. (2001) [Pubmed]
  10. Heterologous desensitization mediated by G protein-specific binding to caveolin. Murthy, K.S., Makhlouf, G.M. J. Biol. Chem. (2000) [Pubmed]
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