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Yong-Jin Wu

Neuroscience Discovery Chemistry

Bristol-Myers Squibb Research and Development

Wallingford

CT 06492

USA

[email]@bms.com

Name/email consistency: high

 
 
 
 
 
 
 

Affiliations

  • Neuroscience Discovery Chemistry, Bristol-Myers Squibb Research and Development, Wallingford, CT 06492, USA. 2009
  • Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA. 2003 - 2005
  • Pfizer Central Research, Eastern Point Road, Groton, Connecticut 06340, USA. 2000 - 2001

References

  1. Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE. Wu, Y.J., Zhang, Y., Good, A.C., Burton, C.R., Toyn, J.H., Albright, C.F., Macor, J.E., Thompson, L.A. Bioorg. Med. Chem. Lett. (2009) [Pubmed]
  2. Recent developments on KCNQ potassium channel openers. Wua, Y.J., Dworetzky, S.I. Curr. Med. Chem. (2005) [Pubmed]
  3. (S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons. Wu, Y.J., Boissard, C.G., Chen, J., Fitzpatrick, W., Gao, Q., Gribkoff, V.K., Harden, D.G., He, H., Knox, R.J., Natale, J., Pieschl, R.L., Starrett, J.E., Sun, L.Q., Thompson, M., Weaver, D., Wu, D., Dworetzky, S.I. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
  4. Synthesis and structure-activity relationship of acrylamides as KCNQ2 potassium channel openers. Wu, Y.J., He, H., Sun, L.Q., L'Heureux, A., Chen, J., Dextraze, P., Starrett, J.E., Boissard, C.G., Gribkoff, V.K., Natale, J., Dworetzky, S.I. J. Med. Chem. (2004) [Pubmed]
  5. Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides. Wu, Y.J., Sun, L.Q., He, H., Chen, J., Starrett, J.E., Dextraze, P., Daris, J.P., Boissard, C.G., Pieschl, R.L., Gribkoff, V.K., Natale, J., Knox, R.J., Harden, D.G., Thompson, M.W., Fitzpatrick, W., Weaver, D., Wu, D., Gao, Q., Dworetzky, S.I. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
  6. (S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine. Wu, Y.J., Boissard, C.G., Greco, C., Gribkoff, V.K., Harden, D.G., He, H., L'Heureux, A., Kang, S.H., Kinney, G.G., Knox, R.J., Natale, J., Newton, A.E., Lehtinen-Oboma, S., Sinz, M.W., Sivarao, D.V., Starrett, J.E., Sun, L.Q., Tertyshnikova, S., Thompson, M.W., Weaver, D., Wong, H.S., Zhang, L., Dworetzky, S.I. J. Med. Chem. (2003) [Pubmed]
  7. Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition. Wu, Y.J., Davis, C.D., Dworetzky, S., Fitzpatrick, W.C., Harden, D., He, H., Knox, R.J., Newton, A.E., Philip, T., Polson, C., Sivarao, D.V., Sun, L.Q., Tertyshnikova, S., Weaver, D., Yeola, S., Zoeckler, M., Sinz, M.W. J. Med. Chem. (2003) [Pubmed]
  8. Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile. Wu, Y.J., He, H., Hu, S., Huang, Y., Scola, P.M., Grant-Young, K., Bertekap, R.L., Wu, D., Gao, Q., Li, Y., Klakouski, C., Westphal, R.S. J. Med. Chem. (2003) [Pubmed]
  9. Recent developments on ketolides and macrolides. Wu, Y.J., Su, W.G. Curr. Med. Chem. (2001) [Pubmed]
  10. Highlights of semi-synthetic developments from erythromycin A. Wu, Y.J. Curr. Pharm. Des. (2000) [Pubmed]
 
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