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Wu, Y.J. et al.

Wu, Boissard, Greco, Gribkoff, Harden, He, L'Heureux, Kang, Kinney, Knox, Natale, Newton, Lehtinen-Oboma, Sinz, Sivarao, Starrett, Sun, Tertyshnikova, Thompson, Weaver, Wong, Zhang, Dworetzky,

(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine.

(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3-phenylacrylamide (2) was synthesized as an orally bioavailable KCNQ2 potassium channel opener. In a rat model of migraine, 2 demonstrated significant oral activity in reducing the total number of cortical spreading depressions induced by potassium chloride.[1]

References

(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine. Wu, Y.J., Boissard, C.G., Greco, C., Gribkoff, V.K., Harden, D.G., He, H., L'Heureux, A., Kang, S.H., Kinney, G.G., Knox, R.J., Natale, J., Newton, A.E., Lehtinen-Oboma, S., Sinz, M.W., Sivarao, D.V., Starrett, J.E., Sun, L.Q., Tertyshnikova, S., Thompson, M.W., Weaver, D., Wong, H.S., Zhang, L., Dworetzky, S.I. J. Med. Chem. (2003) [Pubmed]

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