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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Evan D. Kharasch

Department of Anesthesiology

University of Washington

Seattle 98195

USA

[email]@u.washington.edu

Name/email consistency: high

 
 
 
 
 
 
 

Affiliations

  • Department of Anesthesiology, University of Washington, Seattle 98195, USA. 1997 - 2005
  • University of Washington School of Medicine, Seattle, WA 98195, USA. 2005
  • Anesthesiology Service, Veterans Affairs Medical Center, Seattle, Washington, USA. 1996 - 1997

References

  1. Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies. Kharasch, E.D., Whittington, D., Hoffer, C., Krudys, K., Craig, K., Vicini, P., Sheffels, P., Lalovic, B. Clin. Pharmacokinet (2005) [Pubmed]
  2. CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition. Kharasch, E.D., Thummel, K.E., Watkins, P.B. Mol. Interv. (2005) [Pubmed]
  3. Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity. Kharasch, E.D., Walker, A., Hoffer, C., Sheffels, P. J. Clin. Pharmacol (2005) [Pubmed]
  4. The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone. Kharasch, E.D., Hoffer, C., Whittington, D. Br. J. Clin. Pharmacol (2004) [Pubmed]
  5. Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate. Kharasch, E.D., Whittington, D., Hoffer, C. Anesthesiology (2004) [Pubmed]
  6. Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate. Kharasch, E.D., Hoffer, C., Whittington, D. Anesthesiology (2004) [Pubmed]
  7. Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone. Kharasch, E.D., Hoffer, C., Whittington, D., Sheffels, P. Clin. Pharmacol. Ther. (2004) [Pubmed]
  8. Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis. Kharasch, E.D., Walker, A., Hoffer, C., Sheffels, P. Clin. Pharmacol. Ther. (2004) [Pubmed]
  9. Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity. Kharasch, E.D., Hoffer, C., Walker, A., Sheffels, P. Clin. Pharmacol. Ther. (2003) [Pubmed]
  10. Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine. Kharasch, E.D., Hoffer, C., Whittington, D., Sheffels, P. Clin. Pharmacol. Ther. (2003) [Pubmed]
  11. Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo. Kharasch, E.D., Powers, K.M., Artru, A.A. Anesthesiology (2002) [Pubmed]
  12. Long-duration low-flow sevoflurane and isoflurane effects on postoperative renal and hepatic function. Kharasch, E.D., Frink, E.J., Artru, A., Michalowski, P., Rooke, G.A., Nogami, W. Anesth. Analg. (2001) [Pubmed]
  13. Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity. Kharasch, E.D., Hankins, D.C., Taraday, J.K. Drug Metab. Dispos. (2000) [Pubmed]
  14. Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4. Kharasch, E.D., Hankins, D.C., Fenstamaker, K., Cox, K. Eur. J. Clin. Pharmacol. (2000) [Pubmed]
  15. Clinical isoflurane metabolism by cytochrome P450 2E1. Kharasch, E.D., Hankins, D.C., Cox, K. Anesthesiology (1999) [Pubmed]
  16. Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6, and 3A4 activities: evidence for specificity toward P-450 2E1. Kharasch, E.D., Hankins, D.C., Jubert, C., Thummel, K.E., Taraday, J.K. Drug Metab. Dispos. (1999) [Pubmed]
  17. Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats. Kharasch, E.D., Jubert, C., Spracklin, D.K., Hoffman, G.M. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  18. Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison. Kharasch, E.D., Jubert, C. Anesthesiology (1999) [Pubmed]
  19. Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats. Kharasch, E.D., Hoffman, G.M., Thorning, D., Hankins, D.C., Kilty, C.G. Anesthesiology (1998) [Pubmed]
  20. Single-dose disulfiram does not inhibit CYP2A6 activity. Kharasch, E.D., Hankins, D.C., Baxter, P.J., Thummel, K.E. Clin. Pharmacol. Ther. (1998) [Pubmed]
  21. Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats. Kharasch, E.D., Thorning, D., Garton, K., Hankins, D.C., Kilty, C.G. Anesthesiology (1997) [Pubmed]
  22. Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity. Kharasch, E.D., Frink, E.J., Zager, R., Bowdle, T.A., Artru, A., Nogami, W.M. Anesthesiology (1997) [Pubmed]
  23. Assessment of cytochrome P450 3A4 activity during the menstrual cycle using alfentanil as a noninvasive probe. Kharasch, E.D., Russell, M., Garton, K., Lentz, G., Bowdle, T.A., Cox, K. Anesthesiology (1997) [Pubmed]
  24. The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions. Kharasch, E.D., Russell, M., Mautz, D., Thummel, K.E., Kunze, K.L., Bowdle, A., Cox, K. Anesthesiology (1997) [Pubmed]
  25. Gastroesophageal perforation after intraoperative transesophageal echocardiography. Kharasch, E.D., Sivarajan, M. Anesthesiology (1996) [Pubmed]
 
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