Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL167221 3-nitropyren-1-ol

Synonyms: CCRIS 3452, AG-H-49574, AC1L2XQZ, CTK3E8212, AR-1F4686, ...

Ball, L.M. et al., Qian, D. et al., Howard, P.C. et al.

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High impact information on CCRIS 3452

HPLC revealed that the bile from a 1-NP-treated APBD dog contained mutagenic 1-nitro-6/8-hydroxypyrene and 1-nitro-3-hydroxypyrene, while bile from a 1-NP-treated normal dog did not contain these deconjugated products [1].
The principal metabolite from both P450 forms was 1-nitropyren-3-ol, produced in at least 4-fold greater abundance than the mixture of 1-nitropyren-6-ol and 1-nitropyren-8-ol, or the K-region dihydrodiols [2].
1-Nitropyrene and 3-hydroxy-1-nitropyrene were activated primarily by the 'classical' nitroreductase, while the other compounds, particularly in the presence of S9 metabolic activation, were dependent on transesterification for expression of their mutagenicity [3].

References

Mutagenicity of the bile of dogs with an experimental model of an anomalous arrangement of the pancreaticobiliary duct. Qian, D., Kinouchi, T., Kunitomo, K., Kataoka, K., Matin, M.A., Akimoto, S., Komi, N., Ohnishi, Y. Carcinogenesis (1993) [Pubmed]
The metabolism of 1-nitropyrene by human cytochromes P450. Howard, P.C., Aoyama, T., Bauer, S.L., Gelboin, H.V., Gonzalez, F.J. Carcinogenesis (1990) [Pubmed]
Mutagenicity of derivatives and metabolites of 1-nitropyrene: activation by rat liver S9 and bacterial enzymes. Ball, L.M., Kohan, M.J., Claxton, L.D., Lewtas, J. Mutat. Res. (1984) [Pubmed]

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