The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Biotransformation


Psychiatry related information on Biotransformation


High impact information on Biotransformation


Chemical compound and disease context of Biotransformation


Biological context of Biotransformation


Anatomical context of Biotransformation


Associations of Biotransformation with chemical compounds


Gene context of Biotransformation


Analytical, diagnostic and therapeutic context of Biotransformation


  1. Selective induction of intestinal tumors in rats by methyl(acetoxymethyl)nitrosamine, an ester of the presumed reactive metabolite of dimethylnitrosamine. Joshi, S.R., Rice, J.M., Wenk, M.L., Roller, P.P., Keefer, L.K. J. Natl. Cancer Inst. (1977) [Pubmed]
  2. Transformation of chenodeoxycholic acid to ursodeoxycholic acid in patients with Crohn's disease. Miwa, H., Yamamoto, M., Nishida, T., Yao, T. Gastroenterology (1986) [Pubmed]
  3. Comparison of regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in hepatoma cells grown in vivo and in vitro. Beirne, O.R., Watson, J.A. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  4. Effect of vitamin B12 and folic acid deficiencies on neutrophil function. Kaplan, S.S., Basford, R.E. Blood (1976) [Pubmed]
  5. Comparative effects of paclitaxel and docetaxel on the metabolism and pharmacokinetics of epirubicin in breast cancer patients. Esposito, M., Venturini, M., Vannozzi, M.O., Tolino, G., Lunardi, G., Garrone, O., Angiolini, C., Viale, M., Bergaglio, M., Del Mastro, L., Rosso, R. J. Clin. Oncol. (1999) [Pubmed]
  6. Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome. Liu, S.J., Wang, R.I. The American journal of psychiatry. (1984) [Pubmed]
  7. Toxicokinetics of organic solvents: a review of modifying factors. Löf, A., Johanson, G. Crit. Rev. Toxicol. (1998) [Pubmed]
  8. Effect of short-term starvation and water deprivation on pharmacokinetics of antipyrine in calves. Janus, K. Archivum veterinarium Polonicum / Polish Academy of Sciences, Committee of Veterinary Sciences. (1992) [Pubmed]
  9. Micronucleus test using cultured new born rat astrocytes. Miyakoshi, Y., Suzuki, Y., Ooida, M., Takahashi, A., Tsukui, M. Industrial health. (1999) [Pubmed]
  10. Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse. ul Haque, M.F., King, L.M., Krakow, D., Cantor, R.M., Rusiniak, M.E., Swank, R.T., Superti-Furga, A., Haque, S., Abbas, H., Ahmad, W., Ahmad, M., Cohn, D.H. Nat. Genet. (1998) [Pubmed]
  11. The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone. Lee, J.T., Kroemer, H.K., Silberstein, D.J., Funck-Brentano, C., Lineberry, M.D., Wood, A.J., Roden, D.M., Woosley, R.L. N. Engl. J. Med. (1990) [Pubmed]
  12. The effects of cimetidine on the oxidative metabolism of estradiol. Galbraith, R.A., Michnovicz, J.J. N. Engl. J. Med. (1989) [Pubmed]
  13. Modification of drug biotransformation by vitamin C in man. Houston, J.B., Levy, G. Nature (1975) [Pubmed]
  14. 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. Takeyama, K., Kitanaka, S., Sato, T., Kobori, M., Yanagisawa, J., Kato, S. Science (1997) [Pubmed]
  15. Cyclophosphamide-induced oncogenic transformation, chromosomal breakage, and sister chromatid exchange following microsomal activation. Benedict, W.F., Banerjee, A., Venkatesan, N. Cancer Res. (1978) [Pubmed]
  16. Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. Goetz, M.P., Rae, J.M., Suman, V.J., Safgren, S.L., Ames, M.M., Visscher, D.W., Reynolds, C., Couch, F.J., Lingle, W.L., Flockhart, D.A., Desta, Z., Perez, E.A., Ingle, J.N. J. Clin. Oncol. (2005) [Pubmed]
  17. 23-Methyl-3 alpha,7 beta-dihydroxy-5 beta-cholan-24-oic acid: dose-response study of biliary secretion in rat. Roda, A., Aldini, R., Grigolo, B., Simoni, P., Roda, E., Pellicciari, R., Lenzi, P.L., Natalini, B. Hepatology (1988) [Pubmed]
  18. Effect of side chain length on biotransformation, hepatic transport, and choleretic properties of chenodeoxycholyl homologues in the rodent: studies with dinorchenodeoxycholic acid, norchenodeoxycholic acid, and chenodeoxycholic acid. Yeh, H.Z., Schteingart, C.D., Hagey, L.R., Ton-Nu, H.T., Bolder, U., Gavrilkina, M.A., Steinbach, J.H., Hofmann, A.F. Hepatology (1997) [Pubmed]
  19. Effect of the chemoprotective agent WR-2721 on disposition and biotransformations of ormaplatin in the Fischer 344 rat bearing a fibrosarcoma. Thompson, D.C., Wyrick, S.D., Holbrook, D.J., Chaney, S.G. Cancer Res. (1995) [Pubmed]
  20. Inhibition of 2-fluorenamine-induced mutagenesis in Salmonella typhimurium by vitamin A. Baird, M.B., Birnbaum, L.S. J. Natl. Cancer Inst. (1979) [Pubmed]
  21. Pharmacologic and genetic studies on the modulatory effects of butylated hydroxytoluene on mouse lung adenoma formation. Malkinson, A.M., Beer, D.S. J. Natl. Cancer Inst. (1984) [Pubmed]
  22. Impaired lithocholate sulfation in the rhesus monkey: a possible mechanism for chenodeoxycholate toxicity. Gadacz, T.R., Allan, R.N., Mack, E., Hofmann, A.F. Gastroenterology (1976) [Pubmed]
  23. Modification of chromium(VI)-induced DNA damage by glutathione and cytochromes P-450 in chicken embryo hepatocytes. Cupo, D.Y., Wetterhahn, K.E. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  24. Inhibition of platelet function by organic nitrate vasodilators. Schafer, A.I., Alexander, R.W., Handin, R.I. Blood (1980) [Pubmed]
  25. Cytochrome P-450-dependent monooxygenases in olfactory epithelium of dogs: possible role in tumorigenicity. Dahl, A.R., Hadley, W.M., Hahn, F.F., Benson, J.M., McClellan, R.O. Science (1982) [Pubmed]
  26. Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver. Forrester, L.M., Neal, G.E., Judah, D.J., Glancey, M.J., Wolf, C.R. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  27. Neutrophil iodination reaction induced by fluoride: implications for degranulation and metabolic activation. Clark, R.A. Blood (1981) [Pubmed]
  28. Initial biotransformations of daunorubicin to aglycones by rat liver microsomes. Schwartz, H.S., Parker, N.B. Cancer Res. (1981) [Pubmed]
  29. Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissue microsomes. Placidi, L., Cretton-Scott, E., de Sousa, G., Rahmani, R., Placidi, M., Sommadossi, J.P. Cancer Res. (1995) [Pubmed]
  30. Metabolism of theophylline to caffeine in human fetal liver. Aranda, J.V., Louridas, A.T., Vitullo, B.B., Thom, P., Aldridge, A., Haber, R. Science (1979) [Pubmed]
  31. A model study of fecapentaenes: mutagens of bacterial origin with alkylating properties. Gupta, I., Suzuki, K., Bruce, R.W., Krepinsky, J.J., Yates, P. Science (1984) [Pubmed]
  32. The treatment of acetaminophen poisoning. Prescott, L.F., Critchley, J.A. Annu. Rev. Pharmacol. Toxicol. (1983) [Pubmed]
  33. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Weinshilboum, R.M., Otterness, D.M., Szumlanski, C.L. Annu. Rev. Pharmacol. Toxicol. (1999) [Pubmed]
  34. Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism. Czerwinski, M., McLemore, T.L., Philpot, R.M., Nhamburo, P.T., Korzekwa, K., Gelboin, H.V., Gonzalez, F.J. Cancer Res. (1991) [Pubmed]
  35. Methylation of cytochrome P4501A1 promoter in the lung is associated with tobacco smoking. Anttila, S., Hakkola, J., Tuominen, P., Elovaara, E., Husgafvel-Pursiainen, K., Karjalainen, A., Hirvonen, A., Nurminen, T. Cancer Res. (2003) [Pubmed]
  36. Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens. Le Marchand, L., Sivaraman, L., Pierce, L., Seifried, A., Lum, A., Wilkens, L.R., Lau, A.F. Cancer Res. (1998) [Pubmed]
  37. Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Su, T., Bao, Z., Zhang, Q.Y., Smith, T.J., Hong, J.Y., Ding, X. Cancer Res. (2000) [Pubmed]
  38. Aromatic hydrocarbon receptor (AhR).AhR nuclear translocator- and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells. Mathieu, M.C., Lapierre, I., Brault, K., Raymond, M. J. Biol. Chem. (2001) [Pubmed]
  39. In vitro biotransformations of tetrachloro(d,l-trans)-1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) in rat plasma. Chaney, S.G., Wyrick, S., Till, G.K. Cancer Res. (1990) [Pubmed]
  40. Dietary modifications affecting the mutagenicity of N-nitroso compounds in the host-mediated assay. Zeiger, E. Cancer Res. (1975) [Pubmed]
  41. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. Nebert, D.W., Dalton, T.P., Okey, A.B., Gonzalez, F.J. J. Biol. Chem. (2004) [Pubmed]
  42. Xanthine oxidase catalyzes anaerobic transformation of organic nitrates to nitric oxide and nitrosothiols: characterization of this mechanism and the link between organic nitrate and guanylyl cyclase activation. Li, H., Cui, H., Liu, X., Zweier, J.L. J. Biol. Chem. (2005) [Pubmed]
  43. Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. Probst, M.R., Beer, M., Beer, D., Jenö, P., Meyer, U.A., Gasser, R. J. Biol. Chem. (1994) [Pubmed]
WikiGenes - Universities