Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

LS-52415 4-[(3R,5R,10S,13R,14S,17S)- 3,14-dihydroxy...

Synonyms: AC1L1WG2, 545-52-8, epi-Digitoxigenin, 3-Epidigitoxigenin, 3-alpha-Digitoxigenin, ...

Gobbini, M. et al., Schmoldt, A. et al.

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High impact information on epi-Digitoxigenin

By separation of different sulfotransferases it was found that the hydroxysteroid-ST is responsible for dt-0 and 3-epidigitoxigenin (epi-dt-0) sulfation [1].
The four stereoisomers of the 2-hydroxy derivatives of digitoxigenin and 3-epidigitoxigenin have been synthesized, their structures established by NMR, and their binding affinity for the digitalis receptor on Na+, K(+)-ATPase evaluated [2].

References

Hydroxysteroid sulfotransferase and a specific UDP-glucuronosyltransferase are involved in the metabolism of digitoxin in man. Schmoldt, A., Blömer, I., Johannes, A. Naunyn Schmiedebergs Arch. Pharmacol. (1992) [Pubmed]
Synthesis and biological evaluation of 2-hydroxy derivatives of digitoxigenin and 3-epidigitoxigenin. Gobbini, M., Marazzi, G., Padoani, G., Quadri, L., Valentino, L., Zappavigna, M.P., Melloni, P. Bioorg. Med. Chem. (1998) [Pubmed]

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