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Chemical Compound Review:

Alimet 2-hydroxy-4-methylsulfanyl- butanoic acid

Synonyms: Desmeninol, MHA-FA, MHA acid, AG-G-06566, CHEMBL2104213, ...

Wideman, R.F. et al., Drew, M.D. et al., Vinjamoori, D.V. et al., Hegedüs, M. et al., Lawson, C.Q. et al.

Drew, Van Kessel, Maenz,

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Disease relevance of MHA-FA

Diets supplemented with up to .6% DL-Met (DLM) or .68% 2-hydroxy-4-(methylthio)butanoic acid (HMB, Alimet) acidify the urine and reduce the incidence of urolithiasis in pullets and laying hens [1].

High impact information on MHA-FA

The residual MHA-FA in the distal ileum of germ-free broilers was lower than in conventional birds (4.7 and 10.2% respectively; P < 0.05) [2].
Hydrolysis of 2-hydroxy-4-(methylthio)butanoic acid dimer in two model systems [3].
Bioavailability of methionine-hydroxy-analog free acid and S-methyl-methionine in the growing rat [4].

Analytical, diagnostic and therapeutic context of MHA-FA

Rapid method for determination of 2-hydroxy-4-(methylthio)butanoic acid in poultry feeds by capillary isotachophoresis [5].

References

Responses of laying hens to diets containing up to 2% DL-methionine or equimolar (2.25%) 2-hydroxy-4-(methylthio)butanoic acid. Wideman, R.F., Ford, B.C., Dibner, J.J., Robey, W.W., Yersin, A.G. Poult. Sci. (1994) [Pubmed]
Absorption of methionine and 2-hydroxy-4-methylthiobutoanic acid in conventional and germ-free chickens. Drew, M.D., Van Kessel, A.G., Maenz, D.D. Poult. Sci. (2003) [Pubmed]
Hydrolysis of 2-hydroxy-4-(methylthio)butanoic acid dimer in two model systems. Lawson, C.Q., Ivey, F.J. Poult. Sci. (1986) [Pubmed]
Bioavailability of methionine-hydroxy-analog free acid and S-methyl-methionine in the growing rat. Hegedüs, M., Fekete, S., Andrásofszky, E., Tamás, J., Kövári, L. Acta Vet. Hung. (1992) [Pubmed]
Rapid method for determination of 2-hydroxy-4-(methylthio)butanoic acid in poultry feeds by capillary isotachophoresis. Vinjamoori, D.V., Schisla, R.M. Journal - Association of Official Analytical Chemists. (1986) [Pubmed]

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