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Chemical Compound Review

CCRIS 6889     ethyl 2-chloro-3-oxo-butanoate

Synonyms: E16902_ALDRICH, AG-G-21529, ACMC-209mn7, ANW-33617, NSC-78426, ...
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Disease relevance of Ethyl 2-chloroacetoacetate

  • The utility of this approach was demonstrated by reducing ethyl 2-chloroacetoacetate to the corresponding syn-(2R,3S)-alcohol on a multigram scale using whole cells of an Escherichia coli strain overexpressing a single yeast reductase identified from the screening studies [1].


  1. Stereoselective, biocatalytic reductions of alpha-chloro-beta-keto esters. Kaluzna, I.A., Feske, B.D., Wittayanan, W., Ghiviriga, I., Stewart, J.D. J. Org. Chem. (2005) [Pubmed]
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