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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Stereoselective, biocatalytic reductions of alpha-chloro-beta-keto esters.

Eighteen known and putative reductases from baker's yeast (Saccharomyces cerevisiae) were tested for the ability to reduce a series of alpha-chloro-beta-keto esters. In nearly all cases, it was possible to produce at least two of the four possible alpha-chloro-beta-hydroxy ester diastereomers with high optical purities. The utility of this approach was demonstrated by reducing ethyl 2-chloroacetoacetate to the corresponding syn-(2R,3S)-alcohol on a multigram scale using whole cells of an Escherichia coli strain overexpressing a single yeast reductase identified from the screening studies.[1]


  1. Stereoselective, biocatalytic reductions of alpha-chloro-beta-keto esters. Kaluzna, I.A., Feske, B.D., Wittayanan, W., Ghiviriga, I., Stewart, J.D. J. Org. Chem. (2005) [Pubmed]
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