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Chemical Compound Review

Pyranone     3,5-dihydroxy-2-methyl-5,6- dihydropyran-4-one

Synonyms: CCRIS 8144, SureCN1278394, AC1L3PKW, CTK8D5945, AR-1E9669, ...
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High impact information on Pyranone

  • These studies demonstrate that the integrity of furanocoumarin structure is important for competitive binding to the active site of CYP6B1, even though the carbonyl group on the pyranone ring apparently does not affect its inhibitory capacity, as in the case of furanochromones [1].
  • The pyranone group of compound 2 was found to bind at the active site in the same manner, with the 6-phenyl and the 3-phenylthio occupying P1 and P1', respectively [2].

Analytical, diagnostic and therapeutic context of Pyranone


  1. Inhibition of CYP6B1-mediated detoxification of xanthotoxin by plant allelochemicals in the black swallowtail (Papilio polyxenes). Wen, Z., Berenbaum, M.R., Schuler, M.A. J. Chem. Ecol. (2006) [Pubmed]
  2. Discovery and optimization of nonpeptide HIV-1 protease inhibitors. Tummino, P.J., Prasad, J.V., Ferguson, D., Nouhan, C., Graham, N., Domagala, J.M., Ellsworth, E., Gajda, C., Hagen, S.E., Lunney, E.A., Para, K.S., Tait, B.D., Pavlovsky, A., Erickson, J.W., Gracheck, S., McQuade, T.J., Hupe, D.J. Bioorg. Med. Chem. (1996) [Pubmed]
  3. DNA strand-breaking activity and mutagenicity of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP), a Maillard reaction product of glucose and glycine. Hiramoto, K., Nasuhara, A., Michikoshi, K., Kato, T., Kikugawa, K. Mutat. Res. (1997) [Pubmed]
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