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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Binding Sites

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Disease relevance of Binding Sites


Psychiatry related information on Binding Sites


High impact information on Binding Sites

  • This suggests a model of the RAG protein active site in which two divalent metal ions serve alternating and opposite roles as activators of attacking hydroxyl groups and stabilizers of oxyanion leaving groups [11].
  • TRX is a small multifunctional protein that has a redox-active disulfide/dithiol within the conserved active site sequence: Cys-Gly-Pro-Cys [12].
  • The degenerate binding indicated that the binding site of MHC proteins must have a significant number of conserved features [13].
  • These binding sites are insensitive to the effects of guanine nucleotides and appear to be rapidly internalized [14].
  • Prolyl hydroxylation generates a binding site for a ubiquitin ligase complex containing the von Hippel-Lindau (VHL) tumor suppressor protein, which results in HIFalpha destruction [15].

Chemical compound and disease context of Binding Sites


Biological context of Binding Sites


Anatomical context of Binding Sites


Associations of Binding Sites with chemical compounds


Gene context of Binding Sites

  • The CETP contains binding sites for cholesteryl ester and triglycerides and probably acts by a carrier-mediated mechanism [36].
  • Our results suggest that RAP1 may be a transcriptional regulator that can play a role in either repression or activation of transcription, depending upon the context of its binding site [37].
  • Mutation of the active site of caspase-9 attenuated the activation of caspase-3 and cellular apoptotic response in vivo, indicating that caspase-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP [38].
  • Stimulation depended upon GAL4 binding sites inserted in the template [39].
  • Highly conserved FGF-D2 and FGF-linker (between D2-D3) interfaces define a general binding site for all FGF-FGFR complexes [40].

Analytical, diagnostic and therapeutic context of Binding Sites


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  2. Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4. Peterson, A., Seed, B. Cell (1988) [Pubmed]
  3. Substituting an alpha-helix switches the sequence-specific DNA interactions of a repressor. Wharton, R.P., Brown, E.L., Ptashne, M. Cell (1984) [Pubmed]
  4. Mechanism of action of a yeast activator: direct effect of GAL4 derivatives on mammalian TFIID-promoter interactions. Horikoshi, M., Carey, M.F., Kakidani, H., Roeder, R.G. Cell (1988) [Pubmed]
  5. Studies on the galactose-binding site of ricin and the hybrid toxin Man6P-ricin. Youle, R.J., Murray, G.J., Neville, D.M. Cell (1981) [Pubmed]
  6. [3H]GABA binding in brains from Huntington's chorea patients: altered regulation by phospholipids? Lloyd, K.G., Davidson, L. Science (1979) [Pubmed]
  7. Interaction between purine and benzodiazepine: Inosine reverses diazepam-induced stimulation of mouse exploratory behavior. Crawley, J.N., Marangos, P.J., Paul, S.M., Skolnick, P., Goodwin, F.K. Science (1981) [Pubmed]
  8. Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study. Malizia, A.L., Cunningham, V.J., Bell, C.J., Liddle, P.F., Jones, T., Nutt, D.J. Arch. Gen. Psychiatry (1998) [Pubmed]
  9. Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam. Ferrero, P., Guidotti, A., Costa, E. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  10. A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain. Taipale, M., Kaminen, N., Nopola-Hemmi, J., Haltia, T., Myllyluoma, B., Lyytinen, H., Muller, K., Kaaranen, M., Lindsberg, P.J., Hannula-Jouppi, K., Kere, J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  11. The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Fugmann, S.D., Lee, A.I., Shockett, P.E., Villey, I.J., Schatz, D.G. Annu. Rev. Immunol. (2000) [Pubmed]
  12. Redox regulation of cellular activation. Nakamura, H., Nakamura, K., Yodoi, J. Annu. Rev. Immunol. (1997) [Pubmed]
  13. Interactions between immunogenic peptides and MHC proteins. Rothbard, J.B., Gefter, M.L. Annu. Rev. Immunol. (1991) [Pubmed]
  14. Chemoattractant receptors on phagocytic cells. Snyderman, R., Pike, M.C. Annu. Rev. Immunol. (1984) [Pubmed]
  15. Proline hydroxylation and gene expression. Kaelin, W.G. Annu. Rev. Biochem. (2005) [Pubmed]
  16. Glycine receptor beta-subunit gene mutation in spastic mouse associated with LINE-1 element insertion. Kingsmore, S.F., Giros, B., Suh, D., Bieniarz, M., Caron, M.G., Seldin, M.F. Nat. Genet. (1994) [Pubmed]
  17. CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. Endres, M.J., Clapham, P.R., Marsh, M., Ahuja, M., Turner, J.D., McKnight, A., Thomas, J.F., Stoebenau-Haggarty, B., Choe, S., Vance, P.J., Wells, T.N., Power, C.A., Sutterwala, S.S., Doms, R.W., Landau, N.R., Hoxie, J.A. Cell (1996) [Pubmed]
  18. Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation. Diamond, M.S., Staunton, D.E., Marlin, S.D., Springer, T.A. Cell (1991) [Pubmed]
  19. Site-specific mutagenesis of AIDS virus reverse transcriptase. Larder, B.A., Purifoy, D.J., Powell, K.L., Darby, G. Nature (1987) [Pubmed]
  20. Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution. Doublié, S., Tabor, S., Long, A.M., Richardson, C.C., Ellenberger, T. Nature (1998) [Pubmed]
  21. Protein tyrosine kinase structure and function. Hubbard, S.R., Till, J.H. Annu. Rev. Biochem. (2000) [Pubmed]
  22. G protein mechanisms: insights from structural analysis. Sprang, S.R. Annu. Rev. Biochem. (1997) [Pubmed]
  23. Calcineurin: form and function. Rusnak, F., Mertz, P. Physiol. Rev. (2000) [Pubmed]
  24. Drosophila p53 binds a damage response element at the reaper locus. Brodsky, M.H., Nordstrom, W., Tsang, G., Kwan, E., Rubin, G.M., Abrams, J.M. Cell (2000) [Pubmed]
  25. SV40 gene expression is modulated by the cooperative binding of T antigen to DNA. Myers, R.M., Rio, D.C., Robbins, A.K., Tjian, R. Cell (1981) [Pubmed]
  26. Inhibition of VSV binding and infectivity by phosphatidylserine: is phosphatidylserine a VSV-binding site? Schlegel, R., Tralka, T.S., Willingham, M.C., Pastan, I. Cell (1983) [Pubmed]
  27. Direct evidence for the existence of nominal antigen binding sites on T cell surface Ti alpha-beta heterodimers of MHC-restricted T cell clones. Siliciano, R.F., Hemesath, T.J., Pratt, J.C., Dintzis, R.Z., Dintzis, H.M., Acuto, O., Shin, H.S., Reinherz, E.L. Cell (1986) [Pubmed]
  28. The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Lenardo, M.J., Fan, C.M., Maniatis, T., Baltimore, D. Cell (1989) [Pubmed]
  29. Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke state. Dominguez, R., Freyzon, Y., Trybus, K.M., Cohen, C. Cell (1998) [Pubmed]
  30. Functional activities of autoantibodies to acetylcholine receptors and the clinical severity of myasthenia gravis. Drachman, D.B., Adams, R.N., Josifek, L.F., Self, S.G. N. Engl. J. Med. (1982) [Pubmed]
  31. PTEN and myotubularin: novel phosphoinositide phosphatases. Maehama, T., Taylor, G.S., Dixon, J.E. Annu. Rev. Biochem. (2001) [Pubmed]
  32. Channeling of substrates and intermediates in enzyme-catalyzed reactions. Huang, X., Holden, H.M., Raushel, F.M. Annu. Rev. Biochem. (2001) [Pubmed]
  33. Order out of chaos: assembly of ligand binding sites in heparan sulfate. Esko, J.D., Selleck, S.B. Annu. Rev. Biochem. (2002) [Pubmed]
  34. Structure and functions of the 20S and 26S proteasomes. Coux, O., Tanaka, K., Goldberg, A.L. Annu. Rev. Biochem. (1996) [Pubmed]
  35. Molybdenum-cofactor-containing enzymes: structure and mechanism. Kisker, C., Schindelin, H., Rees, D.C. Annu. Rev. Biochem. (1997) [Pubmed]
  36. Plasma lipid transfer proteins. Tall, A. Annu. Rev. Biochem. (1995) [Pubmed]
  37. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements. Shore, D., Nasmyth, K. Cell (1987) [Pubmed]
  38. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S.M., Ahmad, M., Alnemri, E.S., Wang, X. Cell (1997) [Pubmed]
  39. GAL4 derivatives function alone and synergistically with mammalian activators in vitro. Lin, Y.S., Carey, M.F., Ptashne, M., Green, M.R. Cell (1988) [Pubmed]
  40. Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M. Cell (2000) [Pubmed]
  41. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Angel, P., Hattori, K., Smeal, T., Karin, M. Cell (1988) [Pubmed]
  42. Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis. Kempe, T.D., Swyryd, E.A., Bruist, M., Stark, G.R. Cell (1976) [Pubmed]
  43. Binding of angiotensin and atrial natriuretic peptide in brain of hypertensive rats. Saavedra, J.M., Correa, F.M., Plunkett, L.M., Israel, A., Kurihara, M., Shigematsu, K. Nature (1986) [Pubmed]
  44. The 5S gene internal control region is B-form both free in solution and in a complex with TFIIIA. Gottesfeld, J.M., Blanco, J., Tennant, L.L. Nature (1987) [Pubmed]
  45. Enhancement of TBP binding by activators and general transcription factors. Li, X.Y., Virbasius, A., Zhu, X., Green, M.R. Nature (1999) [Pubmed]
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