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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

DSGG     (2S,4S,5R,6R)-5-acetamido-2- [(2R,3R,4S,5S...

Synonyms: HMDB06588, AR-1G5411, AC1L2Q5B, Disialosylgalactosylgloboside, Disialosyl galactosyl globoside, ...
 
 
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Disease relevance of Disialosyl galactosyl globoside

  • We metabolically 35S labeled these five E. coli isolates and measured their relative binding affinities to serial dilutions of SGG and DSGG as well as to globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4), two other globoseries GSLs present in urogenital tissues [1].
  • Clinicopathological studies revealed that monosialosyl galactosyl globoside (MSGG) and disialosyl galactosyl globoside (DSGG) expressed by renal cell carcinoma (RCC) are one of the biochemical indicator related to the metastatic potential [2].
 

High impact information on Disialosyl galactosyl globoside

  • We previously extracted glycosphingolipids (GSLs) from native VEC and determined that nonsecretors (but not secretors) selectively express two extended globoseries GSLs, sialosyl galactosyl globoside (SGG) and disialosyl galactosyl globoside (DSGG), which specifically bound uropathogenic E. coli R45 expressing a P adhesin [1].
  • We also demonstrated that SGG and DSGG isolated from human kidneys bind uropathogenic E. coli isolates expressing each of the three classes of pap-encoded adhesins, including cloned isolates expressing PapG from J96, PrsG from J96, and PapG from IA2, and the wild-type isolates IA2 and R45 [1].
  • The present study examines the characteristics of four new human RCC cell lines and compares the expression of MSGG and DSGG among them using TLC immunostaining and flow cytometry [2].

References

  1. The globoseries glycosphingolipid sialosyl galactosyl globoside is found in urinary tract tissues and is a preferred binding receptor In vitro for uropathogenic Escherichia coli expressing pap-encoded adhesins. Stapleton, A.E., Stroud, M.R., Hakomori, S.I., Stamm, W.E. Infect. Immun. (1998) [Pubmed]
  2. Four new human renal cell carcinoma cell lines expressing globo-series gangliosides. Satoh, M., Nejad, F.M., Nakano, O., Ito, A., Kawamura, S., Ohyama, C., Saito, S., Orikasa, S. Tohoku J. Exp. Med. (1999) [Pubmed]
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