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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Line

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Disease relevance of Cell Line


Psychiatry related information on Cell Line


High impact information on Cell Line

  • Data from knockout experiments in cell lines and mice have revealed distinct functions for the intracellular protein tyrosine kinases (Lyn, Syk, Btk) in BCR signaling and B cell development [11].
  • Data from recent knockout experiments in cell lines and mice contradict the assumption that Src-family kinase and tyrosine kinases of the Syk/Zap-70 family are the transducer elements that set signaling from these receptors in motion [12].
  • With the use of microfluorescent studies with an established mouse distal convoluted tubule (MDCT) cell line, it was shown that Mg(2+) uptake was concentration and voltage dependent [13].
  • Transduction of wild-type MMACHC into immortalized cblC fibroblast cell lines corrected the cellular phenotype [14].
  • A stable complex containing MLL1 and MOF has been immunoaffinity purified from a human cell line that stably expresses an epitope-tagged WDR5 subunit [15].

Chemical compound and disease context of Cell Line


Biological context of Cell Line


Anatomical context of Cell Line

  • We have generated a series of rat fibroblast cell lines that stably overexpress a full-length cDNA encoding the beta 1 form of protein kinase C (PKC) [26].
  • This property and the expression pattern in tissues and cell lines indicate that RAG-1 either activates or catalyzes the V(D)J recombination reaction of immunoglobulin and T cell receptor genes [27].
  • In several other cell lines, hypusine formation was also observed in a single protein of approximately 18 kd, pI approximately 5.1, indistinguishable electrophoretically from the lymphocyte protein [28].
  • Recombinant IL-20 protein stimulates a signal transduction pathway through STAT3 in a keratinocyte cell line, demonstrating a direct action of this ligand [29].
  • We show that in vitro infection of bone marrow cells with helper-free MPLV readily yields immortalized factor-independent hematopoietic cell lines of different lineages [30].

Associations of Cell Line with chemical compounds

  • The induction of the 46K secreted protein(s) makes these cell lines excellent in vitro systems for studying the mechanism of estrogen and anti-estrogen action [16].
  • Using one such cell line, F9, we have found that retinoic acid at concentrations as low as 10(-9) M induces multiple phenotypic changes in the cultures in vitro [31].
  • The steady state level of the transcripts was under androgen control in three cell lines tested which had low copy numbers of the intact C3 gene, but was not regulated in a cell line which had a very high C3 gene copy number [32].
  • Expression of antisense cDNA or siRNA-like transcripts were used to generate five stable human cell lines deficient in cation-independent mannose 6-phosphate receptors (MPRci) [33].
  • Properties of a basement membrane-related glycoprotein synthesized in culture by a mouse embryonal carcinoma-derived cell line [34].

Gene context of Cell Line

  • During efforts to characterize the interaction of p185c-neu with EGFR further, we created cell lines that simultaneously overexpress both p185c-neu and EGFR and observed that these cells become transformed [35].
  • Viral multiplication was not inhibited by recombinant IFN-alpha/beta in cell lines from the two individuals [36].
  • Analysis of MTS1 in pancreatic carcinomas (27 xenografts and 10 cell lines) showed homozygous deletions in 15 (41%) and sequence changes in 14 (38%) [37].
  • Introduction of cyclin D2 and Rb into the Rb-deficient cell line SAOS-2 led to overt Rb hyperphosphorylation, whereas Rb, expressed alone or together with cyclin D1, remained unphosphorylated [38].
  • In cell lines containing mutations in either gene, we observed increased DNA binding of TCF associated with beta-catenin in nuclei [39].

Analytical, diagnostic and therapeutic context of Cell Line


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  4. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Steck, P.A., Pershouse, M.A., Jasser, S.A., Yung, W.K., Lin, H., Ligon, A.H., Langford, L.A., Baumgard, M.L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D.H., Tavtigian, S.V. Nat. Genet. (1997) [Pubmed]
  5. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. Taplin, M.E., Bubley, G.J., Shuster, T.D., Frantz, M.E., Spooner, A.E., Ogata, G.K., Keer, H.N., Balk, S.P. N. Engl. J. Med. (1995) [Pubmed]
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  8. Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder. Yoon, I.S., Li, P.P., Siu, K.P., Kennedy, J.L., Cooke, R.G., Parikh, S.V., Warsh, J.J. Mol. Psychiatry (2001) [Pubmed]
  9. Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF. Bachoud-Lévi, A.C., Déglon, N., Nguyen, J.P., Bloch, J., Bourdet, C., Winkel, L., Rémy, P., Goddard, M., Lefaucheur, J.P., Brugières, P., Baudic, S., Cesaro, P., Peschanski, M., Aebischer, P. Hum. Gene Ther. (2000) [Pubmed]
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  11. Genetic analysis of B cell antigen receptor signaling. Kurosaki, T. Annu. Rev. Immunol. (1999) [Pubmed]
  12. Initiation and processing of signals from the B cell antigen receptor. Reth, M., Wienands, J. Annu. Rev. Immunol. (1997) [Pubmed]
  13. Magnesium transport in the renal distal convoluted tubule. Dai, L.J., Ritchie, G., Kerstan, D., Kang, H.S., Cole, D.E., Quamme, G.A. Physiol. Rev. (2001) [Pubmed]
  14. Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type. Lerner-Ellis, J.P., Tirone, J.C., Pawelek, P.D., Doré, C., Atkinson, J.L., Watkins, D., Morel, C.F., Fujiwara, T.M., Moras, E., Hosack, A.R., Dunbar, G.V., Antonicka, H., Forgetta, V., Dobson, C.M., Leclerc, D., Gravel, R.A., Shoubridge, E.A., Coulton, J.W., Lepage, P., Rommens, J.M., Morgan, K., Rosenblatt, D.S. Nat. Genet. (2006) [Pubmed]
  15. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Dou, Y., Milne, T.A., Tackett, A.J., Smith, E.R., Fukuda, A., Wysocka, J., Allis, C.D., Chait, B.T., Hess, J.L., Roeder, R.G. Cell (2005) [Pubmed]
  16. A secreted glycoprotein induced by estrogen in human breast cancer cell lines. Westley, B., Rochefort, H. Cell (1980) [Pubmed]
  17. Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos. Hauser, C.A., Joyner, A.L., Klein, R.D., Learned, T.K., Martin, G.R., Tjian, R. Cell (1985) [Pubmed]
  18. Antibodies that promote thyroid growth. A distinct population of thyroid-stimulating autoantibodies. Valente, W.A., Vitti, P., Rotella, C.M., Vaughan, M.M., Aloj, S.M., Grollman, E.F., Ambesi-Impiombato, F.S., Kohn, L.D. N. Engl. J. Med. (1983) [Pubmed]
  19. Regulation of prostaglandin synthesis mediated by thrombin and B2 bradykinin receptors in a fibrosarcoma cell line. Becherer, P.R., Mertz, L.F., Baenziger, N.L. Cell (1982) [Pubmed]
  20. An inducible mammalian amber suppressor: propagation of a poliovirus mutant. Sedivy, J.M., Capone, J.P., RajBhandary, U.L., Sharp, P.A. Cell (1987) [Pubmed]
  21. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Dumont, P., Leu, J.I., Della Pietra, A.C., George, D.L., Murphy, M. Nat. Genet. (2003) [Pubmed]
  22. Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD. Wright, W.E., Sassoon, D.A., Lin, V.K. Cell (1989) [Pubmed]
  23. Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA. Itzhaki, J.E., Gilbert, C.S., Porter, A.C. Nat. Genet. (1997) [Pubmed]
  24. Nerve growth factor mediates phosphorylation of specific proteins. Halegoua, S., Patrick, J. Cell (1980) [Pubmed]
  25. IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc. Shibuya, H., Yoneyama, M., Ninomiya-Tsuji, J., Matsumoto, K., Taniguchi, T. Cell (1992) [Pubmed]
  26. Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Housey, G.M., Johnson, M.D., Hsiao, W.L., O'Brian, C.A., Murphy, J.P., Kirschmeier, P., Weinstein, I.B. Cell (1988) [Pubmed]
  27. RAG-1-deficient mice have no mature B and T lymphocytes. Mombaerts, P., Iacomini, J., Johnson, R.S., Herrup, K., Tonegawa, S., Papaioannou, V.E. Cell (1992) [Pubmed]
  28. Posttranslational formation of hypusine in a single major protein occurs generally in growing cells and is associated with activation of lymphocyte growth. Cooper, H.L., Park, M.H., Folk, J.E. Cell (1982) [Pubmed]
  29. Interleukin 20: discovery, receptor identification, and role in epidermal function. Blumberg, H., Conklin, D., Xu, W.F., Grossmann, A., Brender, T., Carollo, S., Eagan, M., Foster, D., Haldeman, B.A., Hammond, A., Haugen, H., Jelinek, L., Kelly, J.D., Madden, K., Maurer, M.F., Parrish-Novak, J., Prunkard, D., Sexson, S., Sprecher, C., Waggie, K., West, J., Whitmore, T.E., Yao, L., Kuechle, M.K., Dale, B.A., Chandrasekher, Y.A. Cell (2001) [Pubmed]
  30. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Souyri, M., Vigon, I., Penciolelli, J.F., Heard, J.M., Tambourin, P., Wendling, F. Cell (1990) [Pubmed]
  31. The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Strickland, S., Mahdavi, V. Cell (1978) [Pubmed]
  32. Androgen-regulated expression of a cloned rat prostatic c3 gene transfected into mouse mammary tumor cells. Page, M.J., Parker, M.G. Cell (1983) [Pubmed]
  33. Mannose 6-phosphate receptor dependence of varicella zoster virus infection in vitro and in the epidermis during varicella and zoster. Chen, J.J., Zhu, Z., Gershon, A.A., Gershon, M.D. Cell (2004) [Pubmed]
  34. Properties of a basement membrane-related glycoprotein synthesized in culture by a mouse embryonal carcinoma-derived cell line. Chung, A.E., Jaffe, R., Freeman, I.L., Vergnes, J.P., Braginski, J.E., Carlin, B. Cell (1979) [Pubmed]
  35. Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts. Kokai, Y., Myers, J.N., Wada, T., Brown, V.I., LeVea, C.M., Davis, J.G., Dobashi, K., Greene, M.I. Cell (1989) [Pubmed]
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  37. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Caldas, C., Hahn, S.A., da Costa, L.T., Redston, M.S., Schutte, M., Seymour, A.B., Weinstein, C.L., Hruban, R.H., Yeo, C.J., Kern, S.E. Nat. Genet. (1994) [Pubmed]
  38. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Ewen, M.E., Sluss, H.K., Sherr, C.J., Matsushime, H., Kato, J., Livingston, D.M. Cell (1993) [Pubmed]
  39. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Satoh, S., Daigo, Y., Furukawa, Y., Kato, T., Miwa, N., Nishiwaki, T., Kawasoe, T., Ishiguro, H., Fujita, M., Tokino, T., Sasaki, Y., Imaoka, S., Murata, M., Shimano, T., Yamaoka, Y., Nakamura, Y. Nat. Genet. (2000) [Pubmed]
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