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MeSH Review

Flow Cytometry

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Disease relevance of Flow Cytometry


Psychiatry related information on Flow Cytometry

  • DESIGN AND METHODS: Whole blood from patients with HAD, HIV seronegative subjects, and HIV seropositive subjects with no dementia (HIV-ND) was analyzed for CD14/CD69 cells using flow cytometry [6].
  • To evaluate the participation of oxidative stress and defense mechanisms, temporal evolution of intraneuronal free radical generation was monitored by flow cytometry using dihydrorhodamine 123, in parallel with the study of transcriptional, translational, and activity changes of the detoxifying enzymes Cu/Zn-SOD and Mn-SOD [7].
  • The blocking assay, done by flow cytometry, measured anti-idiotypic (Id) reactivity since the sera did not affect the binding of OKT8 (another IgG2a) or anti-Leu4 (another anti-T3), and the blocking activity remained after affinity absorption with normal mouse IgG [8].
  • Using flow cytometry, we measured the relative expression levels of CD45 isoforms, a marker of nai;ve versus memory CD4+ T cell status, on isolated CD4+ T lymphocytes from patients with a clinical diagnosis of probable Alzheimer's disease, normal elderly, cognitively abnormal elderly, and patients with clinically diagnosed other forms of dementia [9].
  • STUDY DESIGN AND METHODS: For blood from vCJD patients, sporadic CJD (sCJD) patients, non-CJD neurological controls, and healthy adults, PrP(c) was measured by DELFIA and cell-associated PrP was measured by flow cytometry [10].

High impact information on Flow Cytometry


Chemical compound and disease context of Flow Cytometry


Biological context of Flow Cytometry


Anatomical context of Flow Cytometry


Associations of Flow Cytometry with chemical compounds

  • Cells were stained with acridine orange, and both RNA and DNA content were determined by flow cytometry [30].
  • Flow cytometry analysis with propidium iodide staining revealed that these p-CTL were specifically deleted by incubation with H-2d ABM, but not with H-2k ABM [31].
  • To elucidate the molecular mechanisms that may explain the functional uncoupling of TCR and CD3, we have analyzed their expression by using flow cytometry as well as immunochemical means both before and after stimulation with anti-TCR-beta, anti-CD3 epsilon, anti-CD2, staphylococcal enterotoxin B, and ionomycin [32].
  • Sialic acid was demonstrated to be the fH target by flow cytometry that showed a fourfold increase in fH binding that was reversed by neuraminidase-mediated cleavage of sialic acid off gonococci [33].
  • To identify these receptors, we generated a monoclonal antibody (mAb), PAL-1, that inhibits hamster AM binding of unopsonized particles (TiO2, Fe2O3, and latex beads; 66 +/- 5, 77 +/- 2, and 85 +/- 2% inhibition, respectively, measured by flow cytometry) [34].

Gene context of Flow Cytometry


Analytical, diagnostic and therapeutic context of Flow Cytometry


  1. Heterogeneity of acute lymphocytic leukemia cell surface markers as detected by monoclonal antibodies. Mann, D.L., Haynes, B.F., Thomas, C., Cole, D., Fauci, A.S., Poplack, D.G. J. Natl. Cancer Inst. (1983) [Pubmed]
  2. Induction of apoptosis by diethylstilbestrol in hormone-insensitive prostate cancer cells. Robertson, C.N., Roberson, K.M., Padilla, G.M., O'Brien, E.T., Cook, J.M., Kim, C.S., Fine, R.L. J. Natl. Cancer Inst. (1996) [Pubmed]
  3. Spontaneous expression of the interleukin 2 receptor gene and presence of functional interleukin 2 receptors on T lymphocytes in the blood of individuals with active pulmonary sarcoidosis. Konishi, K., Moller, D.R., Saltini, C., Kirby, M., Crystal, R.G. J. Clin. Invest. (1988) [Pubmed]
  4. T cell-dependent production of IFN-gamma by NK cells in response to influenza A virus. He, X.S., Draghi, M., Mahmood, K., Holmes, T.H., Kemble, G.W., Dekker, C.L., Arvin, A.M., Parham, P., Greenberg, H.B. J. Clin. Invest. (2004) [Pubmed]
  5. Complement receptor expression on neutrophils at an inflammatory site, the Pseudomonas-infected lung in cystic fibrosis. Berger, M., Sorensen, R.U., Tosi, M.F., Dearborn, D.G., Döring, G. J. Clin. Invest. (1989) [Pubmed]
  6. Changes in monocyte/macrophage neurotoxicity in the era of HAART: implications for HIV-associated dementia. Kusdra, L., McGuire, D., Pulliam, L. AIDS (2002) [Pubmed]
  7. Free radical production and changes in superoxide dismutases associated with hypoxia/reoxygenation-induced apoptosis of embryonic rat forebrain neurons in culture. Lièvre, V., Becuwe, P., Bianchi, A., Koziel, V., Franck, P., Schroeder, H., Nabet, P., Dauça, M., Daval, J.L. Free Radic. Biol. Med. (2000) [Pubmed]
  8. Monoclonal antibody therapy. Anti-idiotypic and non-anti-idiotypic antibodies to OKT3 arising despite intense immunosuppression. Jaffers, G.J., Fuller, T.C., Cosimi, A.B., Russell, P.S., Winn, H.J., Colvin, R.B. Transplantation (1986) [Pubmed]
  9. CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease. Tan, J., Town, T., Abdullah, L., Wu, Y., Placzek, A., Small, B., Kroeger, J., Crawford, F., Richards, D., Mullan, M. J. Neuroimmunol. (2002) [Pubmed]
  10. Variation in concentration of prion protein in the peripheral blood of patients with variant and sporadic Creutzfeldt-Jakob disease detected by dissociation enhanced lanthanide fluoroimmunoassay and flow cytometry. Fagge, T., Barclay, G.R., Macgregor, I., Head, M., Ironside, J., Turner, M. Transfusion (2005) [Pubmed]
  11. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. Hershey, G.K., Friedrich, M.F., Esswein, L.A., Thomas, M.L., Chatila, T.A. N. Engl. J. Med. (1997) [Pubmed]
  12. Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease. Behar, E., Chao, N.J., Hiraki, D.D., Krishnaswamy, S., Brown, B.W., Zehnder, J.L., Grumet, F.C. N. Engl. J. Med. (1996) [Pubmed]
  13. Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria. Miyata, T., Yamada, N., Iida, Y., Nishimura, J., Takeda, J., Kitani, T., Kinoshita, T. N. Engl. J. Med. (1994) [Pubmed]
  14. A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer. Rosell, R., Gómez-Codina, J., Camps, C., Maestre, J., Padille, J., Cantó, A., Mate, J.L., Li, S., Roig, J., Olazábal, A. N. Engl. J. Med. (1994) [Pubmed]
  15. Association of fragile X syndrome with delayed replication of the FMR1 gene. Hansen, R.S., Canfield, T.K., Lamb, M.M., Gartler, S.M., Laird, C.D. Cell (1993) [Pubmed]
  16. Circulating monoclonal B cells expressing P glycoprotein may be a reservoir of multidrug-resistant disease in multiple myeloma. Pilarski, L.M., Belch, A.R. Blood (1994) [Pubmed]
  17. Detection of cytarabine resistance in patients with acute myelogenous leukemia using flow cytometry. Lacombe, F., Belloc, F., Dumain, P., Puntous, M., Makhoul, P.C., Saux, M.C., Bernard, P., Boisseau, M.R., Reiffers, J. Blood (1994) [Pubmed]
  18. Antiproliferative effect of verapamil alone on brain tumor cells in vitro. Schmidt, W.F., Huber, K.R., Ettinger, R.S., Neuberg, R.W. Cancer Res. (1988) [Pubmed]
  19. Isolation and characterization of human melanoma cell variants expressing high and low levels of CD44. Birch, M., Mitchell, S., Hart, I.R. Cancer Res. (1991) [Pubmed]
  20. Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII. Wikstrand, C.J., McLendon, R.E., Friedman, A.H., Bigner, D.D. Cancer Res. (1997) [Pubmed]
  21. Whole animal cell sorting of Drosophila embryos. Krasnow, M.A., Cumberledge, S., Manning, G., Herzenberg, L.A., Nolan, G.P. Science (1991) [Pubmed]
  22. Immunoglobulin-specific suppressor T cells. Lynch, R.G. Adv. Immunol. (1987) [Pubmed]
  23. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. Price, D.A., Brenchley, J.M., Ruff, L.E., Betts, M.R., Hill, B.J., Roederer, M., Koup, R.A., Migueles, S.A., Gostick, E., Wooldridge, L., Sewell, A.K., Connors, M., Douek, D.C. J. Exp. Med. (2005) [Pubmed]
  24. Early T lymphocytes. Differentiation in vivo of adult intrathymic precursor cells. Fowlkes, B.J., Edison, L., Mathieson, B.J., Chused, T.M. J. Exp. Med. (1985) [Pubmed]
  25. Apoptosis of N-type neuroblastoma cells after differentiation with 9-cis-retinoic acid and subsequent washout. Lovat, P.E., Irving, H., Annicchiarico-Petruzzelli, M., Bernassola, F., Malcolm, A.J., Pearson, A.D., Melino, G., Redfern, C.P. J. Natl. Cancer Inst. (1997) [Pubmed]
  26. Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration. Perretti, M., Croxtall, J.D., Wheller, S.K., Goulding, N.J., Hannon, R., Flower, R.J. Nat. Med. (1996) [Pubmed]
  27. Bone marrow cells regenerate infarcted myocardium. Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S.M., Li, B., Pickel, J., McKay, R., Nadal-Ginard, B., Bodine, D.M., Leri, A., Anversa, P. Nature (2001) [Pubmed]
  28. Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent. Zhao, M., Beauregard, D.A., Loizou, L., Davletov, B., Brindle, K.M. Nat. Med. (2001) [Pubmed]
  29. Changes in T-lymphocyte subsets in intravenous drug users with HIV-1 infection. Margolick, J.B., Muñoz, A., Vlahov, D., Solomon, L., Astemborski, J., Cohn, S., Nelson, K.E. JAMA (1992) [Pubmed]
  30. Detection of in vivo stimulated cerebrospinal-fluid lymphocytes by flow cytometry in patients with multiple sclerosis. Noronha, A.B., Richman, D.P., Arnason, B.G. N. Engl. J. Med. (1980) [Pubmed]
  31. Clonal deletion of postthymic T cells: veto cells kill precursor cytotoxic T lymphocytes. Hiruma, K., Nakamura, H., Henkart, P.A., Gress, R.E. J. Exp. Med. (1992) [Pubmed]
  32. Physical dissociation of the TCR-CD3 complex accompanies receptor ligation. Kishimoto, H., Kubo, R.T., Yorifuji, H., Nakayama, T., Asano, Y., Tada, T. J. Exp. Med. (1995) [Pubmed]
  33. A novel sialic acid binding site on factor H mediates serum resistance of sialylated Neisseria gonorrhoeae. Ram, S., Sharma, A.K., Simpson, S.D., Gulati, S., McQuillen, D.P., Pangburn, M.K., Rice, P.A. J. Exp. Med. (1998) [Pubmed]
  34. Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles. Palecanda, A., Paulauskis, J., Al-Mutairi, E., Imrich, A., Qin, G., Suzuki, H., Kodama, T., Tryggvason, K., Koziel, H., Kobzik, L. J. Exp. Med. (1999) [Pubmed]
  35. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. Bochner, B.S., Luscinskas, F.W., Gimbrone, M.A., Newman, W., Sterbinsky, S.A., Derse-Anthony, C.P., Klunk, D., Schleimer, R.P. J. Exp. Med. (1991) [Pubmed]
  36. Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4. Schols, D., Struyf, S., Van Damme, J., Esté, J.A., Henson, G., De Clercq, E. J. Exp. Med. (1997) [Pubmed]
  37. Murine CD9 is the receptor for pregnancy-specific glycoprotein 17. Waterhouse, R., Ha, C., Dveksler, G.S. J. Exp. Med. (2002) [Pubmed]
  38. Small subgroup of aggressive, highly proliferative prostatic carcinomas defined by p53 accumulation. Visakorpi, T., Kallioniemi, O.P., Heikkinen, A., Koivula, T., Isola, J. J. Natl. Cancer Inst. (1992) [Pubmed]
  39. Multiple lymphokine production by a phorbol ester-stimulated mouse thymoma: relationship to cell cycle events. Pearlstein, K.T., Staiano-Coico, L., Miller, R.A., Pelus, L.M., Kirch, M.E., Stutman, O., Palladino, M.A. J. Natl. Cancer Inst. (1983) [Pubmed]
  40. Inherited deficiency of the Mac-1, LFA-1, p150,95 glycoprotein family and its molecular basis. Springer, T.A., Thompson, W.S., Miller, L.J., Schmalstieg, F.C., Anderson, D.C. J. Exp. Med. (1984) [Pubmed]
  41. Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung. Reutershan, J., Morris, M.A., Burcin, T.L., Smith, D.F., Chang, D., Saprito, M.S., Ley, K. J. Clin. Invest. (2006) [Pubmed]
  42. Concurrent expression of erythroid and renal aquaporin CHIP and appearance of water channel activity in perinatal rats. Smith, B.L., Baumgarten, R., Nielsen, S., Raben, D., Zeidel, M.L., Agre, P. J. Clin. Invest. (1993) [Pubmed]
  43. Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells. Dong, Z., Radinsky, R., Fan, D., Tsan, R., Bucana, C.D., Wilmanns, C., Fidler, I.J. J. Natl. Cancer Inst. (1994) [Pubmed]
  44. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. De Caterina, R., Libby, P., Peng, H.B., Thannickal, V.J., Rajavashisth, T.B., Gimbrone, M.A., Shin, W.S., Liao, J.K. J. Clin. Invest. (1995) [Pubmed]
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