Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L2V6X 1,2-dihydroxypyridin-4-one

Synonyms:

Kontoghiorghes, G.J. et al., Kontoghiorghes, G.J.

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High impact information on 1,2-dihydroxypyridin-4-one

The heteroaromatic chelators 1,2-dimethyl-3-hydroxypyrid-4-one, maltol, mimosine and 2,4-dihydroxypyridine-N-oxide, have been shown to mobilize iron from human spleen haemosiderin, ferritin and also from iron(III) precipitates, all containing equal amounts of iron, at physiological pH [1].
A comparative study of the iron chelating properties of 2,4-dihydroxypyridine-N-oxide with heteroaromatic chelators containing an alpha-ketohydroxy binding site has been performed in iron loaded mice labelled with 59Fe lactoferrin [2].

References

Comparative study of iron mobilization from haemosiderin, ferritin and iron(III) precipitates by chelators. Kontoghiorghes, G.J., Chambers, S., Hoffbrand, A.V. Biochem. J. (1987) [Pubmed]
The effect of 2,4-dihydroxypyridine-N-oxide, a new orally active iron chelator, on iron excretion in mice. Kontoghiorghes, G.J. Clin. Chim. Acta (1987) [Pubmed]

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