Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL433366 (6R,7S)-3-[[4-[bis(2- chloroethyl)amino]phe...

Synonyms: AC1L3104, 142478-50-0, 7-Cbnceph mustard, 7-(4-Carboxybutanamido)cephalosporin mustard

Siemers, N.O. et al.

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Disease relevance of 7-Cbnceph mustard

In vitro experiments demonstrated that L49-sFv-bL bound to 3677 melanoma cells expressing the p97 antigen and effected the activation of 7-(4-carboxybutanamido)cephalosporin mustard (CCM), a cephalosporin nitrogen mustard prodrug [1].

References

Construction, expression, and activities of L49-sFv-beta-lactamase, a single-chain antibody fusion protein for anticancer prodrug activation. Siemers, N.O., Kerr, D.E., Yarnold, S., Stebbins, M.R., Vrudhula, V.M., Hellström, I., Hellström, K.E., Senter, P.D. Bioconjug. Chem. (1997) [Pubmed]

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